FOLR3+neutrophils contribute to sepsis by exacerbating hyper-inflammation - Genes & Immunity Genes & Immunity - FOLR3+neutrophils contribute to sepsis by exacerbating hyper-inflammation

🌅 #Research #Alert
FOLR3+ #neutrophils contribute to #sepsis by exacerbating hyper #inflammation

@springernature.com #Genes & #immunity
www.nature.com/articles/s41...

Bcl-xL blockade targets #neutrophils and synergizes with #chemotherapy in #LungSquamousCellCarcinoma

➡️ doi.org/10.1038/s44321-026-00401-z

by A. Mayet, E. Meylan & colleagues @ulbruxelles.bsky.social & University of Lausanne

Way too cool

First time I've heard we can directly see our own white blood cells

Likely #neutrophils since they're the predominant leukocytes in our blood and also move faster than the others

But can't wait to hear the opinion of a rheumatologist...🧪

🔬🦠 Unveiling the role of GSDMD in Streptococcus equi subsp. zooepidemicus infection! This study reveals the critical function of GSDMD in neutrophil extracellular traps (NETs) formation. 🌟🔍

Full article: link.springer.com/article/10.1... 📚🔗

#Neutrophils #GSDMD #ImmuneResponse

🩸Additional insights into disease pathogenesis and diagnosis in Myelofibrosis

#Myelofibrosis #PrimaryMyelofibrosis #Hematology #MPN #HemeOnc #MedEd #BoneMarrow #Anemia #Neutrophils #BloodDisorders #HemeTwitter #HemeHub
@mpnjournal.bsky.social @gmpnsf.bsky.social @rarediseaseadvisor.bsky.social

Available here linda-howes.pixels.com/featured/hum...

#wallartforsale #wallart #gifts #giftideas #Health #Neutrophil #MRSA #Micrography #infection #immuneCel #phagocytosis #bacteria #neutrophils #methicillinResistantStaphylococcusAureus #NatioinalInstituteOfHealthImages

The selective estrogen receptor modulator bazedoxifene affects the metabolism and functions of human neutrophils High doses of bazedoxifene increase cytokine release from neutrophils while impairing antimicrobial functions.

New data from Elena Lonina, Martin Pelletier and colleagues @ulaval.ca @crchudequebec.bsky.social - "The selective estrogen receptor modulator #Bazedoxifene affects the #Metabolism and functions of human #Neutrophils"

Tumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancer How tumor cells overcome anti-tumor immune responses and drive cancer recurrence is not well understood. Yu et al. demonstrate how therapy-resistant breast cancer cells synthesize and secrete arachido...

This week #JournalClub from @LabSoap @cp-immunity.bsky.social #lipid #neutrophils #TNBC #breastcancer #resistance www.cell.com/immunity/abs...

Neutrophils and the NLRP3 inflammasome: a tale of proteases, kinases, and inflammation Cell type–specific mechanisms modulate Nod-like receptor family pyrin domain containing 3 inflammasome activation in macrophages and neutrophils, shaping i

Interested in the #NLRP3 #inflammasome in #neutrophils? Check out our recent review on this topic...: doi.org/10.1093/jleu...

Basal activation of ERK1/2 blunts the antimicrobial activity of neutrophils from old hosts against antibody-opsonized Streptococcus pneumoniae Abstract. Age-related decline in neutrophil function reduces vaccine protection against Streptococcus pneumoniae. In vaccinated hosts, neutrophil activatio

New findings from Shaunna Simmons, Annabel Rivera & @elsaawesomepmns.bsky.social @ubuffalo.bsky.social - "Basal activation of #ERK1/2 blunts the antimicrobial activity of #Neutrophils from old hosts against antibody-opsonized #StreptococcusPneumoniae"

A #circadian checkpoint relocates #neutrophils to minimize injury, from Aroca-Crevillén, Hidalgo @drusqui.bsky.social and colleagues: rupress.org/jem/article/...

📘 In #Hematopoiesis and #Myeloid Cells collection: rupress.org/jem/collecti...

#KSMyeloid26 #KSHemato26

Heart of the matter: #Neutrophils, #cancer, and #CardiovascularDisease. Review from Ambreen, McCarthy, Hidalgo, and @adrover.bsky.social: rupress.org/jem/article/...

📘 In #Hematopoiesis and #Myeloid Cells collection: rupress.org/jem/collecti...

#KSMyeloid26 #KSHemato26

🔥Hot Off the Press | A recent #Cell paper shows that #IL36γ-armored #CART cells can regulate the #TME by reprogramming #neutrophils:
👉Reprogrammed neutrophils: antigen-presenting and tumoricidal functions
🌟Activates cancer-immunity cycle
💡Cure solid tumors in the absence of in vivo #lymphodepletion

Hematopoietic Stem Cells and Myeloid Lineages in Health and Disease | Journal of Experimental Medicine | Rockefeller University Press Advertisement

See our collection of recent findings in the fields of #hematopoiesis and #myeloid lineages, including the role of #neutrophils in myocardial and vascular injury, the characterization of intrarenal myeloid cells, and more: rupress.org/jem/collecti...

Explore recent findings in the fields of #hematopoiesis and #myeloid lineages, including the role of #neutrophils in myocardial and vascular injury, the characterization of intrarenal myeloid cells, & more, to accompany @keystonesymposia.bsky.social meeting on the topic: rupress.org/jem/collecti...

THY1+ cancer stem cells drive metastasis through a pseudohypoxic state shaped by neutrophil-derived mitochondria - Nature Cell Biology Wan, Li, Cao and colleagues report a feedback crosstalk between THY1+ cancer stem cells and neutrophils via migrasome-mediated release of mitochondria, which induces a pseudohypoxic state and promotes...

www.nature.com/articles/s41...

Well this is wild! #Immunometabolism #Neutrophils #Mitochondria

Findings from this PLOS Pathogens study led by Dr. Osamu Takeuchi suggest that Regnase-1 attenuates resistance to #SARS-CoV-2 MA10 infection by promoting excessive interferon responses in #neutrophils.

🤩 Check it out: https://bit.ly/4adJWFp

Aroca-Crevillén, @drusqui.bsky.social et al. identify a #circadian checkpoint in #neutrophils, mediated by the CXCL12–CXCR4 axis, that limits tissue injury by inhibiting their intrinsic circadian clock. rupress.org/jem/article/...

📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...

Multiomics analysis of neutrophils in SLE: insights from adult and paediatric disease In this study we have taken a multiomics approach to study metabolism (NMR Metabolomics) and gene expression (RNA sequencing) in blood neutrophils from adu

Delighted that the 2nd paper from Dr Grace Filbertine is now online, we performed multiomics analysis of #neutrophils from adult and pediatric #SLE patients - similarities & differences reported @livuni-ilcams.bsky.social

academic.oup.com/cei/article/...

A #circadian checkpoint relocates #neutrophils to minimize injury, say Alejandra Aroca-Crevillén, Andrés Hidalgo @drusqui.bsky.social and colleagues @isciiisalud.bsky.social: rupress.org/jem/article/...

#CardiovascularBiology #InnateImmunity #inflammation

Neutrophils recruited to immunization sites initiating vaccine-induced antibody responses by locally expressing BAFF Neutrophils played a key role in the innate immune responses. Less is known about whether and how the neutrophils recruited in the immunization sites …

🔥 #Neutrophils in Vaccine Responses
- Neutrophils are crucial for effective vaccine responses, acting as early responders that help initiate and shape adaptive immunity, particularly antibody production,

#Neutrophils employ several direct & indirect mechanisms to limit viral spread
- Viral Clearance as they eliminate viruses through #phagocytosis (ingesting virions) & degranulation, which releases antimicrobial peptides like α-defensins and cathelicidins

providing critical early protection while also driving severe tissue damage if overactivated & are the most abundant #leukocytes in human circulation & #Neutrophils are among the first immune cells recruited to sites of infection, including those caused by viruses.

#immunosky
#Neutrophils are the first responders of the #innateimmune system recruited to sites of viral infection. Traditionally known for fighting bacteria, they are now recognized as a "double-edged sword" in viral infections,

#Medsky🧪#IDsky #Neurosky @cellpress.bsky.social An overview of the neutrophil lineage, framing it as a "collective" rather than a homogeneous population of cells.
🔑 points include:
🧨 #Neutrophils are organized into 2 distinct compartments

In @jem.org, Aroca-Crevillén, Hidalgo @drusqui.bsky.social et al. identify a #circadian checkpoint in #neutrophils, mediated by the CXCL12–CXCR4 axis, that limits tissue injury by inhibiting their intrinsic circadian clock. rupress.org/jem/article/...

#CardiovascularBiology #InnateImmunity

Aroca-Crevillén, Hidalgo @drusqui.bsky.social et al. identify a #circadian checkpoint in #neutrophils, mediated by the CXCL12–CXCR4 axis, that limits tissue injury by inhibiting their intrinsic circadian clock. rupress.org/jem/article/...

#CardiovascularBiology #InnateImmunity #inflammation

What are #Neutrophils? why are there so many? how are they shaped by disease? how is it that they maintain memory despite their short lifespan?
Our views on this and much more written with #Ivan_Ballesteros for @cp-cell.bsky.social 👇

authors.elsevier.com/a/1mFj9L7PXu...

#Neutrophil-targeted #STAT3 inhibition reshapes #neutrophils into #antitumor effectors, suppresses tumor growth, and boosts cytotoxic CD8⁺ T-cell activity, highlighting STAT3 blockade as a promising #CancerImmunotherapy strategy. @unidue.bsky.social

#STTT: doi.org/10.1038/s413...

This new review outlines the role of cell-mediated #Efferocytosis in clearing #Neutrophils and M1 macrophages, links to M2 polarization, and identifies molecular pathways that serve as targets to improve #TissueRepair. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...