Early and opposing #neutrophil and CD4 T cell responses shape pulmonary #tuberculosis pathology. From @bengern.bsky.social, Michael Gerner, Kevin Urdahl et al. rupress.org/jem/article/...

📘 Updates on the Immune Responses to #TB and #HIV: rupress.org/jem/collecti...
#KSTB26 #KSHIVVax26

New study reveals spleen-to-lung neutrophil axis orchestrates antiviral defense The function of the spleen as an emergency reserve for lung immunity during viral infection has remained obscure. Research led by Professor Xuetao Cao's team at the Chinese Academy of Medical…

#Spleen-to-lung #neutrophil axis orchestrates #antiviral defense ...

| #lungs | #virus | #infection | #respiratory | Via eurekalert .org

Type I IFN drives #neutrophil swarming, impeding lung T cell–#macrophage interactions and #TB control. From William Branchett, Anne O’Garra and colleagues: rupress.org/jem/article/...

📘 Updates on the Immune Responses to #Tuberculosis and #HIV: rupress.org/jem/collecti...
#KSTB26 #KSHIVVax26

#seminar on March 26 at noon by Sandrine Henri (Pathophysiology of lung infections team, @cepru1100.bsky.social, Tours)- #Neutrophil and #Macrophage Heterogeneity in Prostate #Cancer
institutcochin.fr/en/agenda/ne...
@cnrsbiologie.bsky.social @upcite.bsky.social @inserm.fr

MTA1-mediated transcriptional repression of Cox2 confers resistance against neutrophil infiltration in endometritis - Genes & Immunity Genes & Immunity - MTA1-mediated transcriptional repression of Cox2 confers resistance against neutrophil infiltration in endometritis

🌅 #Research #Alert
MTA1-mediated #transcriptional repression of #Cox2 confers #resistance against #neutrophil infiltration in #endometritis

@springernature.com #Genes & #immunity
www.nature.com/articles/s41...

There is more than one way for triple-negative breast cancer to become resistant to therapy The findings point out a potential new approach to treatment in which physicians could take actions to prevent resistance, increasing the chances of patient survival.

Would a patient's #breastCancer develop #resistance to #therapy? X. Zhang, L Yu et al found a way to predict it. @jci.org @bcmhouston.bsky.social #macrophages #neutrophil blogs.bcm.edu/2026/03/03/f...

Available here linda-howes.pixels.com/featured/hum...

#wallartforsale #wallart #gifts #giftideas #Health #Neutrophil #MRSA #Micrography #infection #immuneCel #phagocytosis #bacteria #neutrophils #methicillinResistantStaphylococcusAureus #NatioinalInstituteOfHealthImages

RABEP1 regulates neutrophil migration via endosomal recycling and actin polymerization Rabaptin facilitates fast endosomal recycling, which activates Rac-PAK signaling and reinforces actin polymerization at the neutrophil front to support mot

Daniel Kim, Ramizah Syahirah, Qing Deng and colleagues @cancer-inst-purdue.bsky.social report that #RABEP1 is necessary for #Neutrophil migration - "RABEP1 regulates neutrophil migration via endosomal recycling and actin polymerization"

Available here linda-howes.pixels.com/featured/whi...

#Wallartforsale #wallart #gifts #giftideas #NIAID #Whitebloodcell #MRSA #bacteria #ElectronMicroscope #infection #microbiology #neutrophil #science #Health

Like normal #hillock cells described by Jay Rajagopal's lab, #hillock-like tumor cells are slow-cycling, stress-resistant (especially to platinum and oxidative stress) and exhibit immune-suppressive signatures (especially #neutrophil recruitment). Recent studies suggest pressure on the basal state

A mitochondria-centered subcellular perspective provides a cohesive framework for understanding #neutrophil-tumor communication and may help inform the development of subcellularly targeted cancer therapies.

Learn more from Dr. Bo Pang & colleagues.

📚 https://bit.ly/49MflOQ

#FusobacteriumNucleatum–induced #neutrophil EVs carrying NETs are internalized by intestinal epithelial cells, activating the AIM2 #inflammasome, exacerbating #UlcerativeColitis and highlighting the nEVs–NETs/AIM2 axis as a therapeutic target.

#OpenAccess: doi.org/10.1016/j.ge...

tRF-His-GTG-1 enhances NETs formation and interferon-α production in lupus by extracellular vesicle - Cell Communication and Signaling Background Hyperactive neutrophil extracellular traps (NETs) formation plays a crucial role in active severe systemic lupus erythematosus (SLE). However, what triggers the imbalance in dysregulated NE...

The upregulated tRF-His-GTG-1 is then packaged into pEVs & delivered to neutrophils

link.springer.com/article/10.1...

🧨 Mechanism of #Neutrophil Activation by tRF-His-GTG-1
- Once delivered to neutrophils, tRF-His-GTG-1 interacts with TLR8 n➡️to the activation of neutrophil effector functions

- Severe #COVID & LC are characterized by increased lipid droplet (LD) accumulation & NET release.
🧨The study outlines a dual-pathway mechanism where tRF-His-GTG-1 causes #neutrophil dysfunction
- TLR8–mTOR Activation: tRF-His-GTG-1 binds to Toll-like receptor 8 (TLR8),

Scientists identify #EpothiloneB as a repurposed therapy for #InflammatoryBowelDisease, showing it promotes epithelial repair, reduces #inflammation, rebalances #GutMicrobiota, and induces #neutrophil #apoptosis using #zebrafish screening.

#OpenAccess: doi.org/10.1016/j.ge...

This study shows that #BCL2 inhibitors clear #GiantCongenitalMelanocyticNevus by targeting senescent and proliferative cells, inducing immune infiltration and #neutrophil extracellular traps, and establishing durable memory responses.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Aroca-Crevillén, @drusqui.bsky.social et al. @isciiisalud.bsky.social show that a #circadian #neutrophil checkpoint protects tissues from exuberant #inflammation and can be activated to protect the host. rupress.org/jem/article/...

#CardiovascularBiology #InnateImmunity

Neutrophil Irg1/itaconate axis protects against experimental colitis by suppressing local inflammation and maintaining hematopoietic homeostasis - Molecular Biomedicine Inflammatory bowel disease (IBD) is a chronic, relapsing disorder characterized by excessive inflammation and often associated with extraintestinal symptoms. Current treatments remain unsatisfactory. ...

#Article
Neutrophil Irg1/itaconate axis protects against experimental colitis by suppressing local inflammation and maintaining hematopoietic homeostasis doi.org/10.1186/s435...

#Irg1 #Itaconate #Neutrophil #InflammatoryBowelDisease #ExperimentalColitis #IBD

Altered neutrophil G-protein receptor signalling linked to impaired chemotaxis and increased ROS and NET production in older people with frailty Background: Immune function alters with age, and is often accompanied by chronic, low-grade inflammation (inflammageing). In individuals with frailty, inflammageing is increased, reducing immune funct...

Thrilled to share this pre-print from @gnna.bsky.social PhD. We combine RNAseq with functional experiments to describe #neutrophil phenotype in older people with #frailty
@vivensa.bsky.social @livuni-ilcams.bsky.social

www.medrxiv.org/content/10.6...

Neutrophils in COVID-19: recent insights and advances - Virology Journal Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can lead to acute respiratory distress syndrome (ARDS)...

🧨 Role of #Neutrophil in #Viralinfections
@plos.org
journals.plos.org/plospathogen...
@nature.com
www.nature.com/articles/s41...

www.frontiersin.org/journals/cel...

link.springer.com/article/10.1...

www.frontiersin.org/journals/med...

www.sciencedirect.com/science/arti...

Rainy morning can't make me sad - off to #BSI25 for some #macrophage #neutrophil (and I guess other immune cells exist) fun 😊 don't forget Wednesday 11am 'Recent advances in reproductive immunology'! Going to be fab #immunosky #bestconferenceoftheyear

Inwardly rectifying potassium channels promote directional sensing during #neutrophil chemotaxis, say Tianqi Wang, Daniel Kim, Chang Ding, GuangJun Zhang, Qing Deng, and colleagues (Purdue University) rupress.org/jcb/article/...

#Migration #motility #Immunology

In @jcb.org, Wang, Kim, Ding et al. of the Qing Deng lab demonstrate that inward-rectifying potassium channels maintain the resting membrane potential and are required for directional sensing during #neutrophil chemotaxis. rupress.org/jcb/article/...

Wang, Kim, Ding et al. of the Qing Deng lab demonstrate that inward-rectifying potassium channels maintain the resting membrane potential and are required for directional sensing during #neutrophil chemotaxis. rupress.org/jcb/article/...

Beyond its beautiful, segmented shape 🔬, the #neutrophil nucleus may be a key to understanding immune cell migration and gene regulation - but its full functional relevance remains unknown.

#Immunology #ImmunoSky #CellBiology

🔗 ino.to/bQiWo2g

Discovering Heterogeneous Leukocytes Subsets Associated With Alcoholic Steatohepatitis by scRNAseq Analysis In this study, we explored comprehensive profiling of heterogeneous immune leukocytes at a single-cell level using scRNAseq analysis to discover the regulation of inflammatory-mediated liver fibrosis...

#Article in @MedComm_MC
Discovering Heterogeneous Leukocytes Subsets Associated With Alcoholic Steatohepatitis by #scRNAseq Analysis doi.org/10.1002/mco2...

#AlcoholicLiverDisease #AlcoholicSteatohepatitis #Bcell #ImmuneCell #Neutrophil #tSNEs

This review from Ambreen, @adrover.bsky.social et al. explores cancer-elicited changes to #neutrophil behaviour and proposes ways in which these may contribute to cardiovascular pathology. rupress.org/jem/article/...

📘 In #Cytokines collection: rupress.org/jem/collecti...
#Cytokines2025

Insights @jem.org from Andrea Cooper: Mtb drives expression of type I IFN–mediated #neutrophil accumulation, which limits interaction btwn CD4 T cells & macrophages. Failure to limit type I IFN very early in the process allows rapid progression of disease rupress.org/jem/article/...

#Tuberculosis

Insights from Andrea Cooper: Mtb drives expression of type I IFN–mediated #neutrophil accumulation, which limits interaction btwn CD4 T cells & macrophages. Failure to limit type I IFN very early in the process allows rapid progression of disease rupress.org/jem/article/...

#Tuberculosis

New @jhumimmunity.org study from Valagussa, Kracker et al. identifies and characterizes a novel heterozygous USB1 variant (p.P44L) in a patient with #hypogammaglobulinemia and low #neutrophil counts, showing altered protein localization and function. rupress.org/jhi/article/...