Photo: Members of the research team, from left to right, Martin Schmeing (ball cap), Srobona Ghosh, Mike Tarry, and Anirudh Mantri.

#OnTheBeamlines: Researchers from McGill University are using the CLS to study #enzymes that let #bacteria destroy #itaconate, a small molecule our immune cells make when fighting bacteria. The team's findings could be used to design drugs that block those enzymes. https://bit.ly/4p5UBqq

Photo: Members of the research team, from left to right, Martin Schmeing (ball cap), Srobona Ghosh, Mike Tarry, and Anirudh Mantri.

#OnTheBeamlines: Researchers from McGill University are using the CLS to study #enzymes that let #bacteria destroy #itaconate, a small molecule our immune cells make when fighting bacteria. The team's findings could be used to design drugs that block those enzymes. https://bit.ly/4p5UBqq

Epigenetics Update - ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expression go.nature.com/49Ydk2b

Sriram Venneti (University of Michigan) reporting in Nature

#Epigenetics #Ependymoma #Itaconate
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Discover the breakthrough at epigenometech.com

Photo: Members of the research team, from left to right, Martin Schmeing (ball cap), Srobona Ghosh, Mike Tarry, and Anirudh Mantri.

#OnTheBeamlines: Researchers from McGill University are using the CLS to study #enzymes that let #bacteria destroy #itaconate, a small molecule our immune cells make when fighting bacteria. The team's findings could be used to design drugs that block those enzymes. https://bit.ly/4p5UBqq

Photo: Members of the research team, from left to right, Martin Schmeing (ball cap), Srobona Ghosh, Mike Tarry, and Anirudh Mantri.

#OnTheBeamlines: Researchers from McGill University are using the CLS to study #enzymes that let #bacteria destroy #itaconate, a small molecule our immune cells make when fighting bacteria. The team's findings could be used to design drugs that block those enzymes. https://bit.ly/4p5UBqq

Neutrophil Irg1/itaconate axis protects against experimental colitis by suppressing local inflammation and maintaining hematopoietic homeostasis - Molecular Biomedicine Inflammatory bowel disease (IBD) is a chronic, relapsing disorder characterized by excessive inflammation and often associated with extraintestinal symptoms. Current treatments remain unsatisfactory. ...

#Article
Neutrophil Irg1/itaconate axis protects against experimental colitis by suppressing local inflammation and maintaining hematopoietic homeostasis doi.org/10.1186/s435...

#Irg1 #Itaconate #Neutrophil #InflammatoryBowelDisease #ExperimentalColitis #IBD

Photo: Members of the research team, from left to right, Martin Schmeing (ball cap), Srobona Ghosh, Mike Tarry, and Anirudh Mantri.

#OnTheBeamlines: Researchers from McGill University are using the CLS to study #enzymes that let #bacteria destroy #itaconate, a small molecule our immune cells make when fighting bacteria. The team's findings could be used to design drugs that block those enzymes. https://bit.ly/4p5UBqq

Itaconate reduces viral endocytosis by targeting Cys128 of the adaptor-related protein complex 1 gamma 1 subunit in the host, providing a novel target for antiviral drug development - Molecular Biomed... Traditional antiviral strategies primarily rely on vaccines and virus protein-targeting drugs, which adopt a virus-targeting approach. However, the rapid mutation of viruses often leads to vaccine fai...

#Research
#Itaconate reduces viral endocytosis by targeting Cys128 of the adaptor-related protein complex 1 gamma 1 subunit in the host, providing a novel target for antiviral drug development doi.org/10.1186/s435...

#PostTranslational #modification #Virus #AP1G1 #Clathrin

Big congratulations to my PhD partner in crime @gesaalbers.bsky.social on getting this story out on the role of #itaconate in #asthma and #allergy! First time publishing with PhD dreamteam @helenisinthelab.bsky.social and @gesaalbers.bsky.social, hopefully many more! #immunometabolism #macrophages

I’m so excited to share that my paper on the role of itaconate in allergic airway disease and asthma has just been published in @allergy-eaaci.bsky.social!

You can read the paper here: onlinelibrary.wiley.com/doi/10.1111/...

#itaconate #allergy #asthma #immunometabolism #innateimmunity

Fantastic talk and new data from @lukeanthonyoneill.bsky.social about #mitochondrial control of #inflammation by #itaconate and derivatives in multiple settings #EMDS2025

Silhouette of man with gut microbes and brain being shown, surrounded by food

✨New issue!✨

Check out the latest in #metabolism research!

Read about #Cysteine in #WeightLoss, #GutMicrobiome, #Satiety, #Incretins, #Itaconate - and many more topics!

https://bit.ly/44njRQ5

Molecule Linked to Metabolism Found to Boost Plant Growth | Newswise Researchers have completed the first comprehensive exploration of itaconate, a natural compound involved in metabolism, in plants. The researchers found that itaconate helps plants grow, a finding tha...

Molecule Linked to Metabolism Found to Boost Plant Growth
www.newswise.com/articles/mol...
#plantbiology #PlantGrowth #itaconate #metabolism #crops #food

Speaker Highlight - Luke O'Neill

Delighted that @lukeanthonyoneill.bsky.social from @tcddublin.bsky.social will join us at www.emds2025.com. Looking forward to the #macrophage #metabolism masterclass already! #itaconate #fumarate & much more!

@britsocimm.bsky.social [Background photo:Chris Close]

Itaconate and PRDX5, how did we get here?

Most probably one important piece of the puzzle of #ME/CFS: #Itaconate and PRDX5, how did we get here? Explained by one of the researchers Tom Paulenda communities.springernature.com/posts/itacon...

Itaconate modulates immune responses via inhibition of peroxiredoxin 5 - Nature Metabolism Itaconate is shown to non-covalently inhibit the antioxidant enzyme peroxiredoxin 5 in macrophages, thereby modulating the production of mitochondrial peroxide and enhancing the type I interferon prod...

#ImmunometabolismPower! Artyomov, Paulenda &co show @natmetabolism.nature.com that #itaconate potentiates #interferon production & bloks late NLRP3 activation in response to microbial encounter by inhibiting a mitochondrial peroxidase thus increasing mitochondrial ROS!
www.nature.com/articles/s42...

And keynote speaker of day 2 Karsten Hiller of @tubraunschweig.bsky.social is giving us a deep dive into immuno metabolism in macrophages: #itaconate rules ✌🏻🤓 #Rothenfels2025

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Nano-eradication of Recurrent Bladder Infections: Nanogel+penetrating agent+antibiotic kill bacteria that hide within bladder lining cells and perpetuate urinary tract infections. #cystitis #bladder #infection #itaconate #nanogel #gentamycin
www.instagram.com/reel/DHWrZMm...

Howard G. Smith MD, AM on Instagram: "New Treatment For Alopecia Chemists from the Czech Institute of Organic Chemistry and Biochemistry and the John’s Hopkins Drug Discovery unit have synthesized se... 0 likes, 0 comments - drhowardsmithreports on March 18, 2025: "New Treatment For Alopecia Chemists from the Czech Institute of Organic Chemistry and Biochemistry and the John’s Hopkins Drug Discovery...

New Treatment For Alopecia: Several compounds that, when swallowed and metabolized, create natural anti-inflammatory compounds that can help trigger the regrowth of hair. #alopecia #itaconate #prodrug #baldness #steroids #minoxidil
www.instagram.com/drhowardsmit...

Itaconate is a metabolic regulator of bone formation in homeostasis and arthritis Objectives Bone remodelling is a highly dynamic process dependent on the precise coordination of osteoblasts and haematopoietic-cell derived osteoclasts. Changes in core metabolic pathways during oste...

While #targetedmetabolomics GitHub repository is on private, we published a study where we identify #itaconate, generated as a result of the metabolic reworking during osteoclast differentiation. Kieler et al. Have a look! #multiomics #multiomics #biomed ard.bmj.com/content/83/1...