Itaconate is a metabolic regulator of bone formation in homeostasis and arthritis Objectives Bone remodelling is a highly dynamic process dependent on the precise coordination of osteoblasts and haematopoietic-cell derived osteoclasts. Changes in core metabolic pathways during oste...

While #targetedmetabolomics GitHub repository is on private, we published a study where we identify #itaconate, generated as a result of the metabolic reworking during osteoclast differentiation. Kieler et al. Have a look! #multiomics #multiomics #biomed ard.bmj.com/content/83/1...