Itaconate reduces viral endocytosis by targeting Cys128 of the adaptor-related protein complex 1 gamma 1 subunit in the host, providing a novel target for antiviral drug development - Molecular Biomed... Traditional antiviral strategies primarily rely on vaccines and virus protein-targeting drugs, which adopt a virus-targeting approach. However, the rapid mutation of viruses often leads to vaccine fai...

#Research
#Itaconate reduces viral endocytosis by targeting Cys128 of the adaptor-related protein complex 1 gamma 1 subunit in the host, providing a novel target for antiviral drug development doi.org/10.1186/s435...

#PostTranslational #modification #Virus #AP1G1 #Clathrin

Grech, @jimenezruizlab.bsky.social @meissnerlab.bsky.social show that #Toxoplasma gondii tepsin interacts with the AP4 adaptor complex & #clathrin to mediate #actin- and #myosin F–dependent vesicle trafficking from the trans-#Golgi to the parasite’s #lysosome-like PLVAC rupress.org/jcb/article/...

In @jcb.org, Grech, @meissnerlab.bsky.social et al. show that #Toxoplasma gondii tepsin interacts with the AP4 adaptor complex & #clathrin to mediate #actin- and #myosin F–dependent vesicle trafficking from the trans-#Golgi to the parasite’s #lysosome-like PLVAC rupress.org/jcb/article/...

Rotterdam Floating Pavilion

Floating budding clathrin-coated pits… 🤪
#clathrin #endocytosis
www.insideflows.org/project/rott...

Restaurer la mémoire de Pierre Granche Ses expositions et ses oeuvres d’art public ont fait et font encore voir la ville autrement.

Clathrin-coated vesicles in the subway…
#clathrin #endocytosis
www.ledevoir.com/culture/arts...

Traffic has two calls for papers running: on #clathrin to to celebrate the 50th anniversary of its discovery and #UPS #unconventionalproteinsecretion onlinelibrary.wiley.com/page/journal...

This panel of images illustrates data supporting the report that Clathrin is required for DNA damage repair. Clockwise from upper left: Morphology and relative root lengths of sampled seedlings, GUS staining images of cotyledons, data representing relative HR efficiency, and confocal imaging of subcellular localization of CHC1 and CLC2.

In a new #FreeAccess Brief Communication, Yang et al. report on their identification of #clathrin as participating in the DNA damage response in plants
doi.org/10.1111/jipb...
#PlantScience #endocytosis 🔓

🫧 Is #clathrin involved in the recycling and #exocytosis of endocytosed molecules? Mai Itagaki and Noriyasu Kamei explore this role in a recent article.

➡️ doi.org/10.1002/1873-3468.70016

Coat stiffening can explain invagination of clathrin-coated membranes Clathrin-mediated endocytosis is the main pathway used by eukaryotic cells to take up extracellular material, but the dominant physical mechanisms driving this process are still elusive. Recently, sev...

Interested in #clathrin? Our new paper with @felix-frey.bsky.social on the cooperative curvature model for clathrin-mediated endocytosis is now out in Physical Review E:

doi.org/10.1103/Phys...

Here a short thread to explain the main ideas ... (1/5)