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This study shows that #BCL2 inhibitors clear #GiantCongenitalMelanocyticNevus by targeting senescent and proliferative cells, inducing immune infiltration and #neutrophil extracellular traps, and establishing durable memory responses.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Reviewing #BCL2 family proteins, their regulation & functions, their role in #Apoptosis, with a discussion on the development & potential of BH3-mimetics, #PROTACs, ADCs and tools targeting the BH4 domain of BCL2. @goetheuni.bsky.social

#OpenAccess: doi.org/10.1038/s413...

Integrative Network Pharmacology and Molecular Docking Analyses on the Mechanisms of San-Zhong-Kui-Jian-Tang in Treating Oral Squamous Cell Carcinoma

This study identifies #Quercetin, #Kaempferol, & #Naringenin as promising compounds in SZKJT, a Chinese herbal formulation, targeting #COX2, #TNF, #BCL2, & #Caspase3 to suppress #TumorGrowth, #Inflammation, & #OxidativeStress in OSCC. #medsky

Read: link.springer.com/article/10.1...

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This latest review explores the role of miR-23b in #Cancer, showing how it drives #Tumorigenesis via #Wnt/β-catenin signaling and #Apoptotic proteins such as #BCL2, positioning miR-23b as a potential target in cancer prognosis and therapy. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

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Hematology Weekly News – August 25th 2025 🔬🩸 Hematology Updates: CAR-T in Myeloma, Columvi Approved in Canada, New F8 Mutation and More   From Australia’s first in […] The post Hematology Weekly News – August 25th 2025 appeared first on LucidQuest Ventures.

FYI: LucidQuest Views >>> Hematology Weekly News – August 25th 2025 #News #astrazeneca #BCL2 #BispecificAntibodies Comment below!

Hematology Weekly News – August 25th 2025 🔬🩸 Hematology Updates: CAR-T in Myeloma, Columvi Approved in Canada, New F8 Mutation and More   From Australia’s first in […] The post Hematology Weekly News – August 25th 2025 appeared first on LucidQuest Ventures.

ICYMI: LucidQuest Views >>> Hematology Weekly News – August 25th 2025 #News #astrazeneca #BCL2 #BispecificAntibodies Comment below!

Hematology Weekly News – August 25th 2025 🔬🩸 Hematology Updates: CAR-T in Myeloma, Columvi Approved in Canada, New F8 Mutation and More   From Australia’s first in […] The post Hematology Weekly News – August 25th 2025 appeared first on LucidQuest Ventures.

LucidQuest Views >>> Hematology Weekly News – August 25th 2025 #News #astrazeneca #BCL2 #BispecificAntibodies Comment below!

Hematology Weekly News – June 2nd 2025 🔬🩸 Hematology Updates: CNS Lymphoma Responses, BCL2 Trials, and 5-Year BTK Efficacy From CNS-targeted therapies and real-world CAR-T validation to […] The post Hematology Weekly News – June 2nd 2025 appeared first on LucidQuest Ventures.

FYI: LucidQuest Views >>> Hematology Weekly News – June 2nd 2025 #News #ADC #BCL2 #bloodcancer #BTKInhibitor Comment below!

Hematology Weekly News – June 2nd 2025 🔬🩸 Hematology Updates: CNS Lymphoma Responses, BCL2 Trials, and 5-Year BTK Efficacy From CNS-targeted therapies and real-world CAR-T validation to […] The post Hematology Weekly News – June 2nd 2025 appeared first on LucidQuest Ventures.

ICYMI: LucidQuest Views >>> Hematology Weekly News – June 2nd 2025 #News #ADC #BCL2 #bloodcancer #BTKInhibitor Comment below!

Hematology Weekly News – June 2nd 2025 🔬🩸 Hematology Updates: CNS Lymphoma Responses, BCL2 Trials, and 5-Year BTK Efficacy From CNS-targeted therapies and real-world CAR-T validation to […] The post Hematology Weekly News – June 2nd 2025 appeared first on LucidQuest Ventures.

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#GIT
DEK, p53, and Bcl-2 as CRC biomarkers studied. DEK linked to early carcinogenesis, p53 to advanced stages. Findings aid CRC management. 🔍🔬

#biomarkers #bcl #crc #bcl2
Details: maxapress.com/article/doi/...

Why Bax detection in >1400 publications might be flawed - Cell Death & Disease Cell Death & Disease - Why Bax detection in >1400 publications might be flawed

Just stumbled on this 💎 of a paper at my end-of-the-year review of the #apoptosis #Bax #Bcl2 literature (i.e., trying to get that last paper out). Can't stress enough how glad I am that this gets reported and has a venue in a high profile journal! 🔬🧪👍👍👍 @natureportfolio.bsky.social