Target cell adhesion limits macrophage #phagocytosis and promotes #trogocytosis, say @kirstin-rollins.bsky.social, @mmorrissey.bsky.social and colleagues: rupress.org/jcb/article/...

📕 Part of JCB Immune Cell Biology collection 👉 rupress.org/jcb/collecti...

#AAI2026

Human macrophage phagocytosis of lung cancer cells induced by CD47 blockade is augmented after knockdown of phagocytosis checkpoints mediated by siRNA-loaded lipid nanoparticles The present study demonstrates that siRNA-loaded lipid nanoparticles allow for effective in vitro transfection of human monocyte-derived macrophages and en

Kristian Antonsen and colleagues @au.dk report that "Human #Macrophage #Phagocytosis of #LungCancer cells induced by #CD47 blockade is augmented after knockdown of phagocytosis checkpoints mediated by siRNA-loaded #LipidNanoparticles"

Achucarro Glia School 2026 - Achucarro Basque Center for Neuroscience NOTICE FOR THIS EDITION The Organisation will select participants among the candidates who correctly complete the (pre)Application Form (check the right column). Candidates commit to paying the tuitio...

#AIGS26 | Day 1 (Sept 16) 🧠

Session 1: "Understanding Glial Cells: Cellular Breakthroughs".

Speakers:
🔬 Amanda Sierra @sierralab.bsky.social #microglia #phagocytosis
🔬 Juan Pedro Bolaños @bolanosjuanp.bsky.social #metabolism #mitochondria
🔬 Arne Battefeld #oligodendrocytes #signaling

Available here linda-howes.pixels.com/featured/hum...

#wallartforsale #wallart #gifts #giftideas #Health #Neutrophil #MRSA #Micrography #infection #immuneCel #phagocytosis #bacteria #neutrophils #methicillinResistantStaphylococcusAureus #NatioinalInstituteOfHealthImages

Abhijeet S. Barath and Long-Jun Wu from @mayoclinic.org examine the mechanisms and impact of microglial #phagocytosis in the context of #epilepsy, highlighting unresolved questions that warrant further investigation in this emerging field 🧠 ⚙️

🔗📖 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Moriah's talk is on OBS YouTube channel!
Inhibition of ACAT 1 promotes shedding of soluble #TREM2 and #LRP1-dependent #phagocytosis of amyloid beta protein in #microglia (Alzheimers Dement 2025)

*Speaker: Moriah J Hovde (Massachusetts General Hospital)
youtu.be/Xe6Cn5aFrvU

Target cell cortical tension regulates macrophage trogocytosis - Nature Cell Biology Cornell et al. show that target cells with low cortical tension induce macrophages to preferentially trogocytose, or engulf in small fragments, whereas target cells with high cortical tension tend tow...

☕Cornell et al. show that target cells with low cortical tension induce #macrophages to preferentially trogocytose, or engulf in small fragments, whereas target cells with high #CorticalTension tend towards #phagocytosis.
bit.ly/3L7xFIO

#Neutrophils employ several direct & indirect mechanisms to limit viral spread
- Viral Clearance as they eliminate viruses through #phagocytosis (ingesting virions) & degranulation, which releases antimicrobial peptides like α-defensins and cathelicidins

#phagocytosis congratulations @manondepierre.bsky.social @chiarapompili.bsky.social #PhD #students

Happy to share that I will be presenting at #CellBio2025 this afternoon during the #CSCB session in room 108 our work on #phagocytosis by #macrophages mannose receptor done @institutcochin.bsky.social by @chiarapompili.bsky.social with @jfattaccioli.bsky.social and @jean-Maurice Mallet

⚡Product Citation⚡

In #Alzheimers models generated with StressMarq’s #AmyloidBeta 1-42 Oligomers, scientists demonstrated that enhancing Sox9 in #astrocytes drives #phagocytosis of Aβ plaques and preserves #cognition.

Paper 🌟 https://bit.ly/48q5s7z
Aβ 1-42 Oligomers 🔎 https://bit.ly/4gYWkcj

#Medsky🧪 #immunosky @natrevimmunol.nature.com
In this Review, the researchers examine recent data supporting the idea that the process of #phagocytosis is an integral mechanism of #innateimmune sensing & current efforts to comprehensively define the innate mechanisms at work inside #phagosomes

CD47 inhibits #phagocytosis through Vav dephosphorylation, say Wyatt Miller, Meghan Morrissey (@mmorrissey.bsky.social) and colleagues @ucsantabarbara.bsky.social: rupress.org/jcb/article/...

#Immunology #CellSignaling

🎃Our October issue's out!
Cover: mechanoresponsive #microtubules

👉🏼Reviews: #CellularStress ; #NuclearPoreComplex & #mechanobiology
🔬 #StemCells #senescence #cancer #EndoplasmicReticulum #phagocytosis #pyroptosis #autophagy #PhaseSeparation #AMPK #chromatin & more!
www.nature.com/ncb/volumes/...

Miller, @mmorrissey.bsky.social et al. demonstrate that the CD47 signaling pathway prevents #phagocytosis through dephosphorylation of the Rac GEF Vav. Cancer cells & synthetic targets with CD47 can still be phagocytosed less efficiently through a Rho-dependent mechanism. rupress.org/jcb/article/...

In @jcb.org, @mmorrissey.bsky.social lab demonstrate that the CD47 signaling pathway prevents #phagocytosis through dephosphorylation of the Rac GEF Vav. Cancer cells & synthetic targets w/ CD47 can still be phagocytosed less efficiently through a Rho-dependent mechanism rupress.org/jcb/article/...

Product Citation: New research reveals that traumatic brain injury impairs microglial #phagocytosis and disrupts neuronal activity. Post-impact acrolein accumulation was identified using StressMarq's #Acrolein Antibody.

Paper 🪐 https://bit.ly/46GzS5T
Product details 📚 https://bit.ly/3OreOXF

Target cell adhesion limits macrophage #phagocytosis and promotes #trogocytosis, say @kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al.
@ucsantabarbara.bsky.social rupress.org/jcb/article/...

#Macrophages #Immunology

Membrane receptors cluster phosphatidylserine to activate LC3-associated phagocytosis - Nature Cell Biology Here the authors show that LC3-associated phagocytosis is initiated by various receptors, which enrich phosphatidylserine in the membrane domains proximal to the phagosome, recruiting Rubicon to the membrane for phagosome maturation.

💫NEW: Here the authors show that LC3-associated #phagocytosis is initiated by various receptors, which enrich #phosphatidylserine in the membrane domains proximal to the phagosome, recruiting Rubicon to the membrane for #phagosome maturation.
bit.ly/4qckc2b

#Macrophages are presumed to attack antibody-opsonized #cancer cells by #phagocytosis. In @jcb.org, @kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al find that macrophages attack adherent cells using #trogocytosis, or cell nibbling, instead of phagocytosis. rupress.org/jcb/article/...

@kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al show that #macrophages attack adherent cells using #trogocytosis instead of #phagocytosis. Reducing adhesion increased phagocytosis. Mitotic cells, which disassemble adhesions, are more vulnerable to phagocytosis rupress.org/jcb/article/...

Powerful evidence shared by Roy Maute CEO @pheast.bsky.social to highlight success of PHST001 for targeting the “don’t eat me” #CD24 signal to stimulate #phagocytosis of #cancer cells at tonight’s www.biosf.org BioScience Forum #immunotherapy #ovarian #endometrial #ADCs #surfaceome-targeted_library

Findings on how immune cells use zinc to fight infections challenge long-held beliefs A research team from Umeå University, Sweden, in collaboration with Ghent University, Belgium, has made a groundbreaking discovery about how the body's first immune defense, neutrophils, orchestrate…

How immune cells use #zinc to fight #infections challenge long-held beliefs ...

| #microbes | #neutrophils | #immunesystem | #phagocytosis | By @umeauniversitet.bsky.social via @sciencex.bsky.social

it triggers a robust immune response. This response can include #phagocytosis (cellular engulfment) & antibody-dependent cell-mediated cytotoxicity (ADCC), which kill pathogens or infected cells.
- Avidity: Avidity refers to the overall strength of the binding between an antibody & an antigen.

#Medsky🧪 #Immunosky
The immune system’s primary functions to maintain homeostasis by safeguarding the organism against both external and internal threats. Its toolkit comprises diverse processes, incl #phagocytosis, #antigen recognition, cell killing & the secretion of #cytokines and #antibodies.

N6-methyladenosine RNA modification regulates microglial phagocytosis in the APP/PS1 mouse model of Alzheimer’s disease - Genes & Immunity Genes & Immunity - N6-methyladenosine RNA modification regulates microglial phagocytosis in the APP/PS1 mouse model of Alzheimer’s disease

N6 #methyladenosine #RNA modification regulates #microglial #phagocytosis in the #APP/PS1 #mouse model of #Alzheimer #disease

#Genes & #Immunity @springernature.com
www.nature.com/articles/s41...

Driven to cannibalism: a hormonal trigger for #phagocytosis. Amanda Powell and Elizabeth Ables @eastcarolinauniv.bsky.social discuss new work from Ghosh et al. (rupress.org/jcb/article/...), in Spotlight: rupress.org/jcb/article/...

#Drosophila #Oogenesis #Development

#horrorai #weird #aiimages #iconoplasm #AIArt #AIArtist #AIArtwork #GenArt #DigitalArt #AIArtGallery #AIGeneratedArt #AIArtCommunity #monster #phagocytosis #amoeba #tentacles #hamburger #horrorart #digitalart #fantasyai #synthart #lovecraft

Medium Rare

Glial phagocytosis for synapse and toxic proteins in neurodegenerative diseases - Molecular Neurodegeneration Glia, as resident immune and supportive cells of the central nervous system, play a critical role in maintaining brain homeostasis. One of their key homeostatic functions is phagocytic capacity in pru...

#Glial #phagocytosis for synapse and toxic proteins in #neurodegenerative diseases

Yeseong Choi & Won-Suk Chung

molecularneurodegeneration.biomedcentral.com/articles/10....

JCS poster - Phagocytosis at a glance

In their Cell Science at a Glance article and poster, @manondepierre.bsky.social, @chiarapompili.bsky.social and @florenceniedergang.bsky.social @institutcochin.bsky.social take us through the key features of #phagocytosis.

journals.biologists.com/jcs/article/...