🔬🦠 Unveiling the role of GSDMD in Streptococcus equi subsp. zooepidemicus infection! This study reveals the critical function of GSDMD in neutrophil extracellular traps (NETs) formation. 🌟🔍

Full article: link.springer.com/article/10.1... 📚🔗

#Neutrophils #GSDMD #ImmuneResponse

I am excited to share with you an amazing video on the NLRP3 inflammasome pathway generated by talented Ann Liu from the Janet Iwasa lab @jiwasa.bsky.social @ann-hl.bsky.social. It shows the real structures of the pathway from #NLRP3, #ASC, #caspase-1, #GSDMD, #IL-1b, to #NINJ1. Enjoy!

Emestrin‐Type Epidithiodiketopiperazines Inhibited Gasdermin D‐Mediated Pyroptosis via Caspase‐3/7 Activation This study demonstrates that emestrin-type ETPs suppress GSDMD-mediated pyroptosis through caspase-3/7 activation, thereby attenuating inflammatory responses and conferring protection against sepsis....

#Article in #MedComm
Emestrin-Type Epidithiodiketopiperazines (#ETPs) Inhibited Gasdermin D-Mediated #Pyroptosis via #Caspase-3/7 Activation doi.org/10.1002/mco2...

#gasderminD #GSDMD #sepsis

🔬Pathway Monday | #Pyroptosis
A lytic form of #programmed #cell #death( #PCD) driven by inflammasomes and #GasderminD ( #GSDMD). It releases #IL-1β / #IL-18 and inflammatory mediators, linking pyroptosis to autoimmune and inflammatory diseases.
🧪Explore more: ow.ly/YMz350Xanhv

https://www.cell.com/cell/abstract/S0092-8674(24)01334-5

#NoTimeToDie! @vijayrathinam.bsky.social Weight &co show @cp-cell.bsky.social that pyroptotic cells release extracellular vesicles which transplant gasdermin D #GSDMD pores to neighboring cells propagating cell death! t.co/XgU6jt15aF Free link to the paper 👉 authors.elsevier.com/a/1kMQgL7PXq...

This prompted Mercedes Monteleone from @inflammasomelab.bsky.social to ask whether other effectors of #LyticCellDeath trigger filopodial marks on soon-to-be corpses. #GSDMD, other #gasdermins (#GSDMA, #GSDME) & #MLKL also induce cell assembly of filopodia before cell lysis 😯 (6/13)

Incredibly, minutes before pyroptotic #CellExplosion, cells assemble Myo10-capped #filopodia, which crown the resultant cell corpse. #inflammasome #GSDMD signalling was required for both filopodial assembly & cell death. Might Ca2+ influx via GSDMD pores be involved? 🤔(4/13)

@inflammasomelab.bsky.social star @carolinelholley.bsky.social used a suite of #HighRes #imaging methods to answer these questions, staining the plasma membrane (green) & using an #actin dye that enters via #GSDMD pores during #pyroptosis (purple), to resolve #ExplodingCells (3/13). Watch 👇!