Secondary Necrosis Following Caspase‐Activation can Occur Independently of Gasdermin E Secondary necrosis follows apoptosis, but its mechanism is unclear. This study shows that although gasdermin E is cleaved during this process, it is not required for membrane rupture. Across multiple...

🧬 Just published in Advanced Science: New work from @linkermannlab.bsky.social showing that secondary necrosis can occur without Gasdermin E. A clear step forward in decoding regulated necrosis. #CellDeath #SecondaryNecrosis #GSDME #CaspaseInhibition #AdvancedScience #EditorPick shorturl.at/ITJe6

This prompted Mercedes Monteleone from @inflammasomelab.bsky.social to ask whether other effectors of #LyticCellDeath trigger filopodial marks on soon-to-be corpses. #GSDMD, other #gasdermins (#GSDMA, #GSDME) & #MLKL also induce cell assembly of filopodia before cell lysis 😯 (6/13)