Pyroptosis, a double-edged sword during pathogen infection: a review - Cell Death Discovery Cell Death Discovery - Pyroptosis, a double-edged sword during pathogen infection: a review

#Pyroptosis, a double-edged sword during #pathogen #infection ...

| #celldeath | #virus | #bacteria | #gasdermins | #immunesystem | Via @nature.com

I love myself a good Review with heaps of mechanistic insights!

You do, too? You know what to put on your reading list then 🤩

Bottom line: #pyroptosis is very cool and we're starting to understand quite a bit about how #gasdermins execute this cell death pathway 🥳

Mechanistic insights into gasdermin-mediated pyroptosis - Nature Reviews Molecular Cell Biology Activation of gasdermins (GSDMs) in response to infection or cell damage triggers membrane pore formation, leading to pyroptotic cell death. This Review discusses recent molecular and structural insig...

✨New Review✨

Xing Liu and colleagues highlight recent insights into #pyroptosis, incl. mechanistic insights into how different #gasdermins form pores and the regulation of pyroptosis in health and disease.

👉 go.nature.com/42cfBld

#CellBio #CellDeath

This prompted Mercedes Monteleone from @inflammasomelab.bsky.social to ask whether other effectors of #LyticCellDeath trigger filopodial marks on soon-to-be corpses. #GSDMD, other #gasdermins (#GSDMA, #GSDME) & #MLKL also induce cell assembly of filopodia before cell lysis 😯 (6/13)