Heparin inhibits NLRP3-dependent pyroptosis in acute pancreatitis - Genes & Immunity Genes & Immunity - Heparin inhibits NLRP3-dependent pyroptosis in acute pancreatitis

🌅 #Research #Alert
#Heparin inhibits NLRP3-dependent #pyroptosis in acute #pancreatitis

@springernature.com #Genes & #immunity
www.nature.com/articles/s41...

In this study, researchers developed a conductive coordination #Nanozyme prodrug that triggers synergistic #Pyroptosis, #Cuproptosis, and #Ferroptosis to elicit potent in situ #CancerVaccination and systemic #AntitumorImmunity.

#STTT #OpenAccess: doi.org/10.1038/s413...

Glibenclamide attenuates neuronal #pyroptosis by modulating KATP channels in the hippocampus of palmitic acid-induced lipotoxic mice

www.sciencedirect.com/science/arti... #OpenAccess #inflammasome #inflammation #immunology #ImmunoSky #MedSky

TOLLIP targets GSDME-NT-carrying endocytic vesicles for autophagy to regulate pyroptosis and chemotherapy efficacy - Nature Cell Biology Xu, Li, Deng and colleagues identify a ubiquitin-dependent degradation mechanism for cleaved GSDME mediated by TOLLIP through endocytosis and autophagy. They show this modulates pyroptosis, antitumour...

☕Xu, Li, Deng et al identify a ubiquitin-dependent degradation mechanism for cleaved GSDME mediated by TOLLIP through endocytosis and #autophagy. They show this modulates #pyroptosis, antitumor immunity and #chemotherapy response in mouse models.
👉https://rdcu.be/faqWC
bit.ly/4c9WBtJ

This review highlights #NLRP3 as a key driver of #DiabeticCardiomyopathy, integrating #MetabolicStress to fuel inflammation, #pyroptosis & #fibrosis, and proposes strategies to target NLRP3 to break the metabolism–inflammation cycle.

#OpenAccess: doi.org/10.1016/j.ge...

🌅 #Research #Alert
RETN exacerbates #sepsis by GBP5/NLRP3 #signaling #pathway-mediated #pyroptosis of #macrophage

@springernature.com #Genes & #immunity
👉 Access paper here: www.nature.com/articles/s41...

Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation The cytosolic LPS sensor caspase-4 controls antibacterial immunity by inducing pyroptosis and cytokine secretion. Began et al. show how remodeling of LPS membranes by interferon-induced GTPase GBP1 pr...

Studying #inflammasomes, caspase-4 & #pyroptosis? Learn how the binding affinities of #caspase-4 protein interaction with #lipopolysaccharide (micelles) was enabled by the in-solution measurement of a NanoTemper Technologies Monolith X spectral shift detection

Nur77 induces GSDMC-dependent #Pyroptosis, elucidating a signaling cascade in which Nur77-impaired #HemeHomeostasis triggers PERK/ISR-dependent #GranzymeB activation, providing a novel therapeutic strategy for the treatment of #Melanoma.

#STTT #OpenAccess: doi.org/10.1038/s413...

Symposia

Is there a gasdermin-shaped hole in your life that needs filling? Join us for the SMART Symposium on #Pyroptosis & #Gasdermin Biology in September! Amazing biology & speakers, organised by the wonderful Vishva Dixit, @v-hornung.bsky.social, Feng Shao & Hao Wu!

symposia.smart.org.cn/sym/event/Fu...

IRF2 deficiency disrupts #pyroptosis, NK cell interferon-γ production and #resistance to Francisella.

-> link.springer.com/article/10.1...

#PulsedElectroMagneticFields inhibit #NLRP3 #inflammasome activation, reduce endothelial inflammation and #pyroptosis, restore mitochondrial function via TRPV4 regulation, and delay #atherosclerosis progression, unveiling a mechanobiological pathway.

#STTT: doi.org/10.1038/s413...

AI-powered precision generation of functional peptides targeting the 'undruggable' GSDMD-NT protein, driving a paradigm shift in drug discovery from 'screening' to 'de novo generation'.
doi.org/10.59717/j.x...
#Pyroptosis #drugdiscovery #AIDrugDesign

Emestrin‐Type Epidithiodiketopiperazines Inhibited Gasdermin D‐Mediated Pyroptosis via Caspase‐3/7 Activation This study demonstrates that emestrin-type ETPs suppress GSDMD-mediated pyroptosis through caspase-3/7 activation, thereby attenuating inflammatory responses and conferring protection against sepsis....

#Article in #MedComm
Emestrin-Type Epidithiodiketopiperazines (#ETPs) Inhibited Gasdermin D-Mediated #Pyroptosis via #Caspase-3/7 Activation doi.org/10.1002/mco2...

#gasderminD #GSDMD #sepsis

A novel cross-organ pathogenic communication between #BreastCancer and the heart via the exosomal miR-216a-5p-mediated ITCH/TXNIP/NLRP3 pathway, which drives cardiomyocyte #Pyroptosis, resulting in DOX-induced #Cardiotoxicity (DOXIC).

#STTT #OpenAccess: doi.org/10.1038/s413...

The landscape of regulated cell death: It’s all downhill from here The regulated cell death pathways apoptosis, pyroptosis, and necroptosis are connected on multiple levels. To provide a novel and intuitive conceptual framework of the collaborative and complex nature...

Apoptosis, pyroptosis, necroptosis: distinct pathways, shared chaos.
A conceptual landscape for understanding regulated cell death crosstalk.
#RCD #CellBiology #Apoptosis #pyroptosis
The landscape of regulated cell death: It’s all downhill from here:
@molecular-cell
www.cell.com/molecular-ce...

Client Challenge

#Research
Activated oligoadenylate synthetase-ribonuclease L pathway promotes endothelial #pyroptosis and impairs diabetic wound healing via thioredoxin-interacting protein #m6A #methylation doi.org/10.1186/s435...

#OAS_RNaseL #TXNIP #LPS #DiabeticWound

A20 curbs oxidized self-DNA–driven #inflammation in #AKI by suppressing #STINGsignaling and blocking #NLRP3-mediated #pyroptosis via NEK7; an A20-derived peptide improves survival and #RenalInjury, highlighting a promising strategy.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Nur77-mediated disruption of heme homeostasis induces GSDMC-dependent #Pyroptosis, highlighting a novel Nur77/heme metabolism/ISR signaling axis and a new paradigm for the therapeutic induction in #MetastaticMelanoma.

#STTT #OpenAccess: doi.org/10.1038/s413...

#PulsedElectromagneticFields suppress NLRP3-driven endothelial #inflammation and #pyroptosis, restore mitochondrial function by modulating membrane-tension–regulated TRPV4 channels, and significantly slow #atherosclerosis progression.

#OpenAccess in #STTT: doi.org/10.1038/s413...

MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death - Nature Cell Biology Nguyen, Collier et al. find a mitochondria–lysosome inflammatory pathway regulated by the SUMO E3 ligase MAPL, which promotes vesicular mtDNA transport to lysosomes and subsequent gasdermin-dependent ...

☕Nguyen, Collier et al. find a #mitochondria – #lysosome inflammatory pathway regulated by the SUMO E3 ligase MAPL, which promotes vesicular mtDNA transport to lysosomes and subsequent gasdermin-dependent lysosomal permeabilization to activate #pyroptosis.
bit.ly/4oF4Fqb

Oleic acid restores the impaired antitumor immunity of γδ-T cells induced by palmitic acid - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Oleic acid restores the impaired antitumor immunity of γδ-T cells induced by palmitic acid

#DietaryFattyAcids regulate γδ-T cell #antitumor activity, where #PalmiticAcid induces IFNγ-mediated #pyroptosis reducing efficacy, while #OleicAcid restores function, offering a novel strategy to enhance γδ-T cell #immunotherapy.4

#OpenAccess in #STTT: doi.org/10.1038/s413...

Graphical abstract of the original paper, source: original paper

🧬 New research finds activating the cGAS–#STING pathway in human #monocytes triggers a unique form of regulated cell death — a blend of #apoptosis and #pyroptosis dubbed “pyroptotic apoptosis.” This links mitochondrial stress to immune signaling and inflammation.

🔗 buff.ly/6EoEosJ

(MK)

A new insight into the mechanism of DEHP-induced cardiotoxicity: Triggering pyroptosis of cardiomyocytes by disrupting sphingolipid metabolism The widespread use of di(2-ethylhexyl) phthalate (DEHP) as a plasticizer raises concerns due to its environmental persistence and cardiotoxicity. Neve…

#bioinformatics #publichealth #gerontology #pyroptosis #cardiology #exposome #ecology #health

Exposure to the plasticizer DEHP
causes
- accumulation of its metabolite MEHP in the heart,
- activation of the SPHK1/S1PR2 pathway,
- heart damage and fibrosis.
.
www.sciencedirect.com/science/arti...

#DietaryFattyAcids regulate γδ-T cell #antitumor activity, where #PalmiticAcid induces IFNγ-mediated #pyroptosis reducing efficacy, while #OleicAcid restores function, offering a novel strategy to enhance γδ-T cell #immunotherapy.

#OpenAccess in #STTT: doi.org/10.1038/s413...

3/9 This scaffold is the key. The #caspases must be brought together to kill the cell; it is their proximity to one another that activates them.

This isn't quiet, programmed cell death (apoptosis).

The mechanism triggers #pyroptosis —a violent, inflammatory self-destruction.

🎃Our October issue's out!
Cover: mechanoresponsive #microtubules

👉🏼Reviews: #CellularStress ; #NuclearPoreComplex & #mechanobiology
🔬 #StemCells #senescence #cancer #EndoplasmicReticulum #phagocytosis #pyroptosis #autophagy #PhaseSeparation #AMPK #chromatin & more!
www.nature.com/ncb/volumes/...

🔬Pathway Monday | #Pyroptosis
A lytic form of #programmed #cell #death( #PCD) driven by inflammasomes and #GasderminD ( #GSDMD). It releases #IL-1β / #IL-18 and inflammatory mediators, linking pyroptosis to autoimmune and inflammatory diseases.
🧪Explore more: ow.ly/YMz350Xanhv

The higher resolution, significantly improved apo crystal structure of mouse gasdermin D will be beneficial for structure-based drug-design approaches towards this important pharmacological target #Pyroptosis #Inflammation #GasderminD doi.org/10.1107/S205...

Exosomal transfer of pro-pyroptotic miR-216a-5p exacerbates anthracycline cardiotoxicity through breast cancer-heart pathological crosstalk - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Exosomal transfer of pro-pyroptotic miR-216a-5p exacerbates anthracycline cardiotoxicity through breast cancer-heart pathological crosstalk

#Doxorubicin-treated #BreastCancer cells release #exosomal miR-216a-5p, which suppresses ITCH, stabilizes TXNIP, and activates the NLRP3 inflammasome to trigger #cardiomyocyte #pyroptosis. #cardiotoxicity @fudan-university.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

Myeloid-specific CD38 deficiency activates the SIRT1-p53/PPARγ signaling in macrophages, which in turn mitigates hepatic #OxidativeStress, #Inflammation, & NLRP3-induced #pyroptosis, leading to improved hepatic I/R injury. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...