#ApoptosisvsNecrosis31
#CellDeath #Pathology #MedicalEducation #Caspases #ProgrammedCellDeath #Bcl2 #MitochondrialPathway #ExtrinsicPathway #IntrinsicPathway #CoagulativeNecrosis #LiquefactiveNecrosis #GangrenousNecrosis #CaseousNecrosis #FatNecrosis #FibrinoidNecrosis #Histopathology #MedicalNotes

3/9 This scaffold is the key. The #caspases must be brought together to kill the cell; it is their proximity to one another that activates them.

This isn't quiet, programmed cell death (apoptosis).

The mechanism triggers #pyroptosis —a violent, inflammatory self-destruction.

2/9 How does it work?

Researchers found about 100 special #immune #proteins hang out inside every cell, just waiting. When a #virus breaks in, it "seeds a crystal."

The proteins instantly clump around it, forming a scaffold for #enzymes known as #caspases to activate.

Hi all, my name is Malvina. I am a senior postdoctoral researcher trying my best to start my lab and study the regulation of the immune system by cardiolipin and mitochondria. I am passionate about #inflammasome #caspases and #mitochondria, and I advocate #equity #diversity and #inclusion in science

Gutenberg #ResearchAward goes to #cell death researcher Vishva Dixit - http://www.uni-mainz.de/presse/20253_ENG_HTML.php #apoptosis #caspases