Emestrin‐Type Epidithiodiketopiperazines Inhibited Gasdermin D‐Mediated Pyroptosis via Caspase‐3/7 Activation This study demonstrates that emestrin-type ETPs suppress GSDMD-mediated pyroptosis through caspase-3/7 activation, thereby attenuating inflammatory responses and conferring protection against sepsis....

#Article in #MedComm
Emestrin-Type Epidithiodiketopiperazines (#ETPs) Inhibited Gasdermin D-Mediated #Pyroptosis via #Caspase-3/7 Activation doi.org/10.1002/mco2...

#gasderminD #GSDMD #sepsis

🔬Pathway Monday | #Pyroptosis
A lytic form of #programmed #cell #death( #PCD) driven by inflammasomes and #GasderminD ( #GSDMD). It releases #IL-1β / #IL-18 and inflammatory mediators, linking pyroptosis to autoimmune and inflammatory diseases.
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The higher resolution, significantly improved apo crystal structure of mouse gasdermin D will be beneficial for structure-based drug-design approaches towards this important pharmacological target #Pyroptosis #Inflammation #GasderminD doi.org/10.1107/S205...

Gasdermin D emerges as a potential therapeutic target for atrial fibrillation This study reveals that gasdermin D plays a novel role in the development of atrial fibrillation through multifaceted mechanisms.

Researchers N. Li, Y Yuan et al identified #gasderminD as a potential contributor to #atrialFibrillation. #EurHeartJ #BCMDeptMedicine #heartDisease @bcmhouston.bsky.social #BCMHeart #jmartinlab blogs.bcm.edu/2025/03/27/f...

What is Pyroptosis? Pyroptosis is a type of programmed cell death that is inflammatory and alerts the immune system. It's triggered by the protein Gasdermin D (GSDMD), which forms pores in the cell membrane. 2/6 #Pyroptosis #GasderminD