It’s the #filopodia, stupid! 🚀
We just released our new study uncovering how filopodia and hydrostatic #pressure contribute to the regulation of #membrane #tension.
👉 Check it out on bioRxiv: biorxiv.org/content/10.1...
#cellbiology #biophysics #actin #mechanobiology

Breakthrough discovery about cell migration may finally help us defeat cancer Scientists reveal how filopodia help cancer spread. The breakthrough could improve treatments that stop cancer cells from invading tissues.

Breakthrough discovery about cell migration will help defeat cancer: Scientists reveal how filopodia help cancer spread. The breakthrough could improve treatments that stop cancer cells from invading tissues.

#CellMigration #Filopodia #CancerResearch #Metastasis #StructuralBiology #EarthDotCom

Why do #pyroptotic cells use their final minutes to make #filopodia? Well, #filopodia are rich stores of F-actin under the plasma membrane. Could #CellExplosion during #pyroptosis reveal filopodial F-actin to engage the corpse antigen sampling DC receptor, #CLEC9A/#DNGR1? (10/13) (credit: BioRender)

Incredibly, minutes before pyroptotic #CellExplosion, cells assemble Myo10-capped #filopodia, which crown the resultant cell corpse. #inflammasome #GSDMD signalling was required for both filopodial assembly & cell death. Might Ca2+ influx via GSDMD pores be involved? 🤔(4/13)

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm

As my official introduction to the blue sky. Here is a TIRF image of #HeLa cells forming and elongating its beautiful #filopodia! @tyskalabactual.bsky.social

I made a starter pack for cytoskeleton people
#cytoskeleton #microtubules #actin #cilia #filopodia #tunnelingnanotubes

go.bsky.app/TF83cpi

What are the differences among #Filopodia #Cytoneme #TunnelingNanotube

Size? Duration? Cargo? Cytoskeleton? Signaling?

Take a look at this nice, up-to-date synthesis😋👇

Actin-based protrusions at a glance

#JCellSci 2023
journals.biologists.com/jcs/article/...