Now online - research briefing from @inflammasomelab.bsky.social Mercedes Monteleone on our recent @natimmunol.bsky.social publication on how pyroptotic cell corpses signal to dendritic cells from beyond the grave! #inflammasomes #pyroptosis #CellDeath #CLEC9A
Link: rdcu.be/d30EL

Summary: pyroptotic & necroptotic cells assemble F-actin-rich filopodia to ⛳️ their corpses. Filopodia mark corpses for recognition by #DCs, via the corpse antigen sampling receptor, #CLEC9A.
New questions: Does this trigger Ag-specific immunity in #infection, #vaccination & #autoimmunity? 🤯 (12/13)

In clever expts by Inflammasome Lab's Sabrina Burgener, DCs reacted to the calcium-sensitive filopodia of corpses by phosphorylating SYK via #CLEC9A. While #NINJ1-driven #CellExplosion was not needed for filopodial assembly (L; M. Monteleone), it was required to expose F-actin to #CLEC9A🤯. (11/13)