We found that enhancing neuronal activity via #tDCS coupled with low-intensity physical activity accelerates #remyelination and increases #oligodendroglia survival and maturation in a model of #myelin damage in the mouse motor cortex

The research network #BRAVEinMS, led by #UniSR Proff. Gianvito Martino and Paola Panina, has identified #bavisant as a promising candidate for #neuroprotection and #remyelination in progressive #MultipleSclerosis.

Read more: www.unisr.it/en/news/2026...

More Hope for Re-myelination Therapy An effective re-myelination drug is one of the holy grails of treatment for MS. That would mean less damage, and potential reversibility of some of the ongoing damage, before neurons have become be…

msmartinecom.wordpress.com/2025/12/18/m...

#MultipleSclerosis #Remyelination #myelin #blog #disability #neurology

PIPE-307 shows potential to repair myelin in MS mouse model Treatment with PIPE-307, currently in Phase 2 testing for RRMS, was shown to promote remyelination in a mouse model of multiple sclerosis.

That was promising, as so many others failed trials (sigh)

Happy Mouses: so many 🐀🐁🐭 "cured" but what about us ppwMS ?? Still #NoCure 🫤

#Pipe-307
#Remyelination remains an unmet medical need

multiplesclerosisnewstoday.com/news-posts/2...

Illustration of a thoughtful woman surrounded by puzzle pieces, with text asking about a breakthrough in myelin repair for MS. "MultipleSclerosisNewsToday.com" is noted as source at bottom.

ICYMI: New research could “help deliver on the promise of regenerative therapies that MS patients so urgently need.” See how: https://bit.ly/3IJPDzK

#MS #MultipleSclerosis #MSResearch #MSTreatment #MSCommunity #MyelinRepair #Remyelination #MSNews #Bionews

Illustration of a thoughtful woman surrounded by puzzle pieces, with text asking about a breakthrough in myelin repair for MS. "MultipleSclerosisNewsToday.com" is noted as source at bottom.

New research could “help deliver on the promise of regenerative therapies that MS patients so urgently need.” See how: https://bit.ly/3JNmOmn

#MS #MultipleSclerosis #MSResearch #MSTreatment #MSCommunity #MyelinRepair #Remyelination #MSNews #Bionews

Illustration of damaged myelin sheath with text highlighting remyelinating therapies' potential to promote neuroprotection in RRMS. "MultipleSclerosisNewsToday" is noted as source at bottom.

Researchers looked at data from a trial testing bexarotene, a cancer treatment, in MS. See what they found about the relationship between remyelination and nerve fiber damage: https://bit.ly/4lbu7B1

#MS #MSResearch #MSTreatment #MSNews #Remyelination #Bionews

Remyelination of chronic demyelinated lesions with directly induced neural stem cells Peruzzotti-Jametti et al. examine the remyelination potential of mouse- and human-derived directly induced neural stem cell (iNSC) grafts. They show that i

Thrilled to share our latest paper showing that the transplantation of directly induced neural #StemCells enhances #remyelination of chronic demyelinating lesions!
💉🧠=💪
A great team effort with @pluchinolab.bsky.social and all our collaborators! #MultipleSclerosis

academic.oup.com/brain/advanc...

Nalfurafine promotes myelination in vitro and facilitates recovery from cuprizone + rapamycin‐induced demyelination in mice Nalfurafine increased oligodendrocyte progenitor cell (OPC) differentiation and nanofibers myelination in OPC cultures. In mice, nalfurafine facilitated recovery from time-dependent cuprizone + rapa...

A new study explored nalfurafine, a well-tolerated kappa opioid receptor (KOR) agonist, in MS models. The goal? Promote remyelination by targeting KOR. #Remyelination #TranslationalResearch

📄 Read the study
onlinelibrary.wiley.com/doi/full/10....

Demyelination produces a shift in the population of cortical neurons that synapse with callosal oligodendrocyte progenitor cells Oligodendrocyte progenitor cells (OPCs) receive synaptic input from a diverse range of neurons in the developing and adult brain. Understanding whether the neuronal populations that synapse with OPCs ...

Demyelination Produces a Shift in the Population of Cortical Neurons That Synapse with Callosal Oligodendrocyte Progenitor Cells

#neuro #oligodendroglia #OPC #myelination #remyelination #demyelination #neuron #synapse 🧪

doi.org/10.1523/ENEU...

Rewind Therapeutics Builds Stronger Advisory Board with Neurology Experts for Remyelination Therapy Rewind Therapeutics has added four esteemed neurologists to its Scientific Advisory Board, enhancing its capabilities as it moves forward with its groundbreaking GPR17 remyelination therapy aimed at neurological disorders.

Rewind Therapeutics Builds Stronger Advisory Board with Neurology Experts for Remyelination Therapy #Belgium #Leuven #Rewind_Therapeutics #GPR17 #Remyelination

Novel @cellanome.bsky.social platform tracks #NeuralSTEMCell differentiation & isoform shifts to boost #WM1 repair via #remyelination therapies for #MS & #CerebralPalsy! Here is neuron caged for longitudinal #phenotypic analysis of live #NSCs differentiation into #neurons, #astro, and #OLs🧬🧠🔬🥼🧪🧫

Top left: Representative immunofluorescent labeling of oligodendrocyte lineage cells (Olig2+, green) which are mature (CC1+, magenta) in Csf1r-iCre;Porcfl/fl compared to Porcfl/fl control mice at 14 dpl, counterstained with Hoechst. Scale bar, 20 μm. Bottom left: Representative immunofluorescent labeling of oligodendrocyte lineage cells (Olig2+, green) which are mature (CC1+, magenta) in Vehicle-treated and C59-treated monocyte transplanted mice at 10 dpl, counterstained with Hoechst. Scale bar, 20 μm. Right: Graphical abstract of results: Classical monocytes support oligodendrocyte differentiation and myelin protein expression, yet impede myelin production during remyelination in a Wnt-dependent manner.

#Remyelination in the CNS is influenced by myeloid cells, including resident #microglia & infiltrating #monocytes. @mironlab.bsky.social &co show that infiltrating monocytes inhibit the efficiency of CNS remyelination @plosbiology.org 🧪 plos.io/3RryCLF

Top left: Representative immunofluorescent labeling of oligodendrocyte lineage cells (Olig2+, green) which are mature (CC1+, magenta) in Csf1r-iCre;Porcfl/fl compared to Porcfl/fl control mice at 14 dpl, counterstained with Hoechst. Scale bar, 20 μm. Bottom left: Representative immunofluorescent labeling of oligodendrocyte lineage cells (Olig2+, green) which are mature (CC1+, magenta) in Vehicle-treated and C59-treated monocyte transplanted mice at 10 dpl, counterstained with Hoechst. Scale bar, 20 μm. Right: Graphical abstract of results: Classical monocytes support oligodendrocyte differentiation and myelin protein expression, yet impede myelin production during remyelination in a Wnt-dependent manner.

#Remyelination in the CNS is influenced by myeloid cells, including resident #microglia & infiltrating #monocytes. @mironlab.bsky.social &co show that infiltrating monocytes inhibit the efficiency of CNS remyelination @plosbiology.org 🧪 plos.io/3RryCLF

Top left: Representative immunofluorescent labeling of oligodendrocyte lineage cells (Olig2+, green) which are mature (CC1+, magenta) in Csf1r-iCre;Porcfl/fl compared to Porcfl/fl control mice at 14 dpl, counterstained with Hoechst. Scale bar, 20 μm. Bottom left: Representative immunofluorescent labeling of oligodendrocyte lineage cells (Olig2+, green) which are mature (CC1+, magenta) in Vehicle-treated and C59-treated monocyte transplanted mice at 10 dpl, counterstained with Hoechst. Scale bar, 20 μm. Right: Graphical abstract of results: Classical monocytes support oligodendrocyte differentiation and myelin protein expression, yet impede myelin production during remyelination in a Wnt-dependent manner.

#Remyelination in the CNS is influenced by myeloid cells, including resident #microglia & infiltrating #monocytes. @mironlab.bsky.social &co show that infiltrating monocytes inhibit the efficiency of CNS remyelination @plosbiology.org 🧪 plos.io/3RryCLF

Developments in the quest to reverse Multiple Sclerosis damage I do a fair bit of “mini-research” on MS to understand more fully the mechanisms behind it and especially to see what hope there might be in the pipeline. The very process of writing this blog, wit…

msmartinecom.wordpress.com/2025/03/30/d... #multiplesclerosis #blog #remyelination #research #clinicsltrials #hope

Gut-punch to anyone hoping on better treatments and cures for #multiplesclerosis #cancer #diabetes #mentalillness #alzheimers #pediatricillness and more
The majority of funding for #MS research is from #NIH
I had a lot of hope for the trials on #remyelination

😞😡 #keepsmyelin 🙃

ClinicalTrials.gov

People with #MultipleSclerosis: “We need #remyelination and #brainRegeneration therapies”

The world: We got a trial on the Effects of Laughter Yoga on Fatigue, Sleep Quality and Psychological Well-Being in Patients With Multiple Sclerosis!

clinicaltrials.gov/study/NCT067...

#MSchat #Neurology

First clinical trial of MS remyelination therapy PTD802 cleared in... PTD802 is a selective inhibitor of the GPR17 receptor and is made to restore myelin, a process known as remyelination, in multiple sclerosis.

This can't happen fast enough for me! #MSWarrior #MSActivist #MSRepair #Remyelination #MyelinRepair
multiplesclerosisnewstoday.com/news-posts/2...

Pheno Therapeutics granted clinical trial authorization for lead multiple sclerosis therapeutic candidate PTD802 Pheno Therapeutics Limited., a biotechnology company focused on the discovery and development of small molecule therapeutics for the treatment of neurological diseases, announced today it has received...

#MultipleSclerosis

"... A selective GPR17 (G protein-coupled receptor 17) antagonist, PTD802 is a novel small molecule therapeutic designed to promote #remyelination..."

#remyelination a huge unmet medical need in MS.

Many trials failed in the past.

And MS has no cure as many other diseases.

Pheno Therapeutics granted trial authorisation for MS candidate - PharmaTimes First-in-human trial of PTD802 to commence following UK MHRA approval

#PhenoTherapeutics #Firstinhumantrial #PTD802 #clinicaltrialauthorisation #CTA #smallmoleculetherapeutic #remyelination #multiplesclerosis #MS #neurology #selectiveGPR17antagonist #UCB #Demyelination #DemyelinationinMS #GPR17targetingremyelinationtherapeutics
pharmatimes.com/news/pheno-t...

Thx 🙏 for sharing, let’s be hopeful

#MultipleSclerosis
#remyelination

The protein kinase C modulator bryostatin-1 therapeutically targets microglia to attenuate neuroinflammation and promote remyelination Protein kinase C modulation with bryostatin-1 enables innate immune cells in the central nervous system to promote myelin repair and regeneration.

Excited to share our new work identifying PKC as a druggable target for modulating microglia in order to enhance myelin repair. 🧵 #remyelination #multiplesclerosis www.science.org/doi/10.1126/...

Wish I could say something helpful. In October it was 12 years for me they are working on #remyelination I’m praying it works. It’s in phase 2 🐍

#remyelination #oc