This support means a lot to us, not just as funding, but as trust in the work we’re doing. Building on the results we got in a former Telethon project, we aim now at optimizing an #oligodendroglia cell replacement strategy to sustain #neurodevelopment in a preclinical model of #microcephaly MCPH17

We found that enhancing neuronal activity via #tDCS coupled with low-intensity physical activity accelerates #remyelination and increases #oligodendroglia survival and maturation in a model of #myelin damage in the mouse motor cortex

Brilliant PhD defense today by Carla Peiró on myelin as an energy supplier! 🔬⚡️@upv/ehu uncovering how #myelin fuels #oligodendroglia. Outstanding work and its contribution to understanding #brain #energy #metabolism @matutelab.bsky.social @iisbiobizkaia @labdomercq @achucarro.bsky.social @ciberned

Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing - Nature Neuroscience Dissecting the adaptive exercise response of the neurogenic stem-cell niche in the dentate gyrus by single-nucleus RNA sequencing reveals the molecular mediators that underlie exercise’s protective ef...

Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing

#neuroprotection #neurodegenration #oligodendroglia #neurogenesis #microglia #astrocyte #myelination #exercise #singlecell #transcriptomics 🧪

doi.org/10.1038/s415...

Single-cell chromatin accessibility profiling reveals regulatory mechanisms and evolution in pig brains - BMC Biology Background Pig brains serve as a valuable biomedical model for studying brain-related diseases due to their significant structural similarities to the human brain. Furthermore, the long-term domestica...

Single-cell chromatin accessibility profiling reveals regulatory mechanisms and evolution in pig brains

#singlecell #epigenome #transcriptome #RNAseq #ATACseq #cortex #cerebellum #oligodendroglia 🧪

bmcbiol.biomedcentral.com/articles/10....

Demyelination produces a shift in the population of cortical neurons that synapse with callosal oligodendrocyte progenitor cells Oligodendrocyte progenitor cells (OPCs) receive synaptic input from a diverse range of neurons in the developing and adult brain. Understanding whether the neuronal populations that synapse with OPCs ...

Demyelination Produces a Shift in the Population of Cortical Neurons That Synapse with Callosal Oligodendrocyte Progenitor Cells

#neuro #oligodendroglia #OPC #myelination #remyelination #demyelination #neuron #synapse 🧪

doi.org/10.1523/ENEU...

Big congrats to Maryam K. Ardakani who defended her PhD thesis on approaches targeting #oligodendroglia in models of primary autosomal recessive #microcephaly 17!

And a big thank you to Prof. F Ferrini (UniTo), Prof. A Frasca (UniMi), Prof. De Meffre (Université Paris Cité) for serving as commitee!