Epigenetics Update - BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes
bit.ly/4kxXPSa
Costas A. Lyssiotis and Yatrik M. Shah (University of Michigan) reporting in Mol Cell
#Epigenetics #BRD4 #Mitochondria
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Discover the breakthrough at epigenometech.com
#Epigenetic factor #BRD4: Discerning its role as central regulator of #LungDevelopment with implications to understand its function in adult #LungBiology and disease insight.jci.org/articles/vie... #BromodomainContainingProtein4 #TranslationalScience
For anyone interested in #BRD4 and #Polycomb axis in development, please check out 👇 latest preprint from our lab.
How does acidity affect #ImmuneCells?
The @xuzhoulab.bsky.social at @bostonchildrens.bsky.social found that a drop in pH can suppress immune responses by disrupting a protein called #BRD4.
🥼 Abstract in @cellpress.bsky.social: https://bit.ly/3IZDAhP
✏️ Press release: https://on.bchil.org/48rhZtf
So Happy to contribute a small part to this work from my PhD supervisor, Dr. Xi-Long Zheng lab 😆
The role of epigenomic reader #BRD4 in #SmoothMuscleCell #Microtubule #Autophagy #Senescence #IntimalHyperplasia #VascularAging😎
#ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
Talk announcement: Pradeepa Madapura, "Mechamisms through which BRD4 regulates transcription elongation and loop extrusion", 18 March, 12:00. MR3.1, Jeffrey Cheah Biomedical Centre
Attention Cambridge, UK People!
Check out this seminar, Tuesday 18 March 12:00 at the CSCI @scicambridge.bsky.social!
@pradeepmadapura.bsky.social talking about #Brd4, #Transcription and #LoopExtrusion.
Completely different from his recent Epigenetics Club sem.
#BRD4 #Senescence #Ferroptosis
"Acquired vulnerability to ferroptosis induction in senescent tumor cells following combination treatment cotargeting CDK4/6 (palbociclib) & BRD4 (I-BET726)"
#CancerRes 2024
aacrjournals.org/cancerres/ar...
#LongNoncodingRNA #SmoothMuscleCell #Seneascence #Atherosclerosis
LncRNA JPX (just proximal to XIST), in complex with #BRD4 NF-κB, transcriptionally activates #SASP in senescent SMCs
SMC Jpx KO⏬🐭#Atherosclerosis +⏬lesional SMC senescence SASP
#ATVB 2024
www.ahajournals.org/doi/10.1161/...
#BRD4 #HematopoieticStemCell
A powerful story🤓
Induced hematopoietic (Mx1-Cre + pI:pC) KO of BRD4 in adult🐭
▶️Death in 3 wk
▶️Loss of Hematopoietic stem/progenitor cell self-renewal
⏫#Senescence of HSC
Transcriptomic + epigenomic analysis
#EmboReports 2023
www.embopress.org/doi/full/10....
