Landmark revisit
#YAP #Senescence

YAP/TEAD-mediated transcription controls cellular senescence

Double shRNAs P53 + P16 only rescue 25% fibroblast senescence by shYAP

Cdk6 as a direct YAP target gene
shRNA Cdk6 or Rb rescues 50% senescence

#CancerRes 2013
aacrjournals.org/cancerres/ar...

#NasoPharyngealCarcinoma

Dormant Polyploid Giant Cancer Cell
👉induced by paclitaxel in vitro, cisplatin in🐭
👉depends on AMPK-RIPK1-mTOR-Autophagy axis
👉gives birth to small daughter cells in vitro🤓

Histo PGCC#▶️
⏫lymph/distant metastasis
⏬survival

#CancerRes 2022
aacrjournals.org/cancerres/ar...

So proud of the delaPuenteLab presence in the Eastern South Dakota Research Symposium. Simona received a Best Oral Presentation Poster Award, Amrita was selected as one of the 4 trainees to give an oral presentation, and Karla and Kristin presented posters #WomenInSTEM #CancerRes

SETDB1-H3K9me3 represses #EndogenousRetroVirus transcription

SETDB1 CRISPR KO⏫ERV➡️
⏫MDA5-MAVS RNA sensing➡️
⏫IRF7 interferon signal➡️
⏫T cell infiltr
⏫Irradiation sensitiv in B16F10 🐭tumor

SETDB1 ➖corr. #NSCLC #SKCM -free survival with #RadioTherapy

#CancerRes 2022
aacrjournals.org/cancerres/ar...

#BRD4 #Senescence #Ferroptosis

"Acquired vulnerability to ferroptosis induction in senescent tumor cells following combination treatment cotargeting CDK4/6 (palbociclib) & BRD4 (I-BET726)"

#CancerRes 2024
aacrjournals.org/cancerres/ar...