#SETDB1 #EndogenousRetroVirus

Pax7+ #MuSC, but not Pdgfra+ FAP, SETDB1 KO🐭➡️defected #SkeletalMuscle Regeneration
50%⏬muscle mass

Loss of SETDB1-H3K9me3 in MuSC depresses ERV expression ▶️
⏫cGAC-STING-IRF3▶️
⏬proliferation ⏫cell death ⏫pro-inflamm cytokines

#DevCell 2025
www.cell.com/developmenta...

SETDB1-H3K9me3 represses #EndogenousRetroVirus transcription

SETDB1 CRISPR KO⏫ERV➡️
⏫MDA5-MAVS RNA sensing➡️
⏫IRF7 interferon signal➡️
⏫T cell infiltr
⏫Irradiation sensitiv in B16F10 🐭tumor

SETDB1 ➖corr. #NSCLC #SKCM -free survival with #RadioTherapy

#CancerRes 2022
aacrjournals.org/cancerres/ar...

RBBP4, a histone chaperone, establishes Heterochromatin on sites of #EndogenousRetroVirus
Recruits G9a (H3K9me2) to ERVL elements; KAP1 (H3K9me3) to ERV1/ERVK elements

"degradation of RBBP4, but not RBBP7, reprograms mESCs to the totipotent 2C-like cells"

#NAR 2023
academic.oup.com/nar/article/...

#Senescence-associated #EndogenousRetroVirus

#ATF3 ➡️bidirectional transcription of SA-ERV (ERV1 ERVK ERVL ERVL-MaLR)
➡️⏫ RIG-I/MDA5-MAVS- interferon I & #Senescence

SA-ERV transcripts ⏫in skin nerve muscle adipose & blood during👤#Aging

#NatureAging 2024
www.nature.com/articles/s43...