Single-cell omics🐭#OvarianAging
scRNAseq scATACseq
12- vs 3-mo

#Aging
1⃣Mesenchymal Phox2B/ESRRγ/HoxB7-TGFβ2➡️ #Fibrosis (steroidogenic stroma, fibroblast, theca, but NOT pericyte)
2⃣Granulosa cell HSPA5 #ATF3 ATF4➡️#ERStress

Any #VascularAging?

#GeroScience 2025
link.springer.com/article/10.1...

#Senescence-associated #EndogenousRetroVirus

#ATF3 ➡️bidirectional transcription of SA-ERV (ERV1 ERVK ERVL ERVL-MaLR)
➡️⏫ RIG-I/MDA5-MAVS- interferon I & #Senescence

SA-ERV transcripts ⏫in skin nerve muscle adipose & blood during👤#Aging

#NatureAging 2024
www.nature.com/articles/s43...

Ahhhh, kijk nou! Wat schattig! #ditiseenmobieltje #atf3 #1996 http://twitpic.com/5giwua