#VascularAging
Smooth muscle cell estrogen receptor α promotes arterial stiffness in the absence of estradiol😎
Evidence from
1⃣Ovariectomy ♀️🐭
2⃣Acta2-CreERT2+ SMC KO of ERα ♂️♀️🐭
SMC ERα KO ⏬arterial stiffness (PWV), not fibrosis, in aged (18-mo)♂️♀️🐭😮
bioRxiv 2026
www.biorxiv.org/content/10.6...
#Autophagy #VascularAging
SM22α+ #SmoothMuscleCell Atg7 KO🐭3.5 mo
Aorta myography with oscillatory tension 10 Hz
👉Peterson modulus⏫
pressure-dependent
systolic 80~300 mmHg
diastolic 40~260 mmHg
↔️🫀functions
Paul Fransen lab #PflügersArchiv 2020
link.springer.com/article/10.1...
This review highlights #VascularAging and #ArterialStiffness as key drivers of #CardiovascularDisease, detailing structural and functional changes, end‑organ damage, measurement methods, and prevention/therapy strategies.
#OpenAccess in #STTT: doi.org/10.1038/s413...
11th Edition Aging & Gerontology
April 20–21, 2026 | Dubai, UAE
Second Round Abstract Submission Ends: January 25, 2026
agingcongress.com/edition2//ab...
Fasting boosts mitochondria, improves endothelial health, and cuts inflammation.
#VascularAging #EndothelialFunction
This review explores #VascularAging and #ArterialStiffness as key drivers of #CVD, detailing structural and functional changes, #EndOrganDamage, measurement methods, and emerging therapeutic targets for interdisciplinary translational research.
#STTT: doi.org/10.1038/s413...
Summarizing the pathophysiology underlying #VascularAging & #ArterialStiffness, the resulting end-organ damage and methods for measuring arterial stiffness, with highlights on preventive & therapeutic strategies and future directions. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
This review outlines the mechanisms of #VascularAging & #ArterialStiffness, their effects on end-organ damage, measurement techniques, potential preventive & therapeutic strategies, and future directions for research. #CVD #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
🩺 Mild COVID-19 can age blood vessels by 5 years, raising heart disease and stroke risks. 💉 Vaccination offers protection against vascular aging. #COVID19 #VascularAging #HeartHealth #StrokeRisk #BreakInNews
5/12 The numbers are striking. Non-hospitalised COVID women had +0.55 m/s PWV increase, hospitalised women +0.60 m/s, and ICU women +1.09 m/s.
This translates to roughly 5-7.5 years of accelerated vascular aging and 3-5.5% increased CV risk.
#VascularAging #CVRisk
Huge congrats to Beth Cheshire (not on Bluesky) whose project this was (and her first paper!) 👏👏👏
Big thanks to the whole team as well @lbeishon.bsky.social, SJ Messeder, Coral Pepper and Rob Sayers!
More to come from us on #CognitiveImpairment and #PAD 👀
#VascularAging
4/4
Understanding Thoracic Aortic Disease in Women
♀️➡️3-fold⏫risk of Dissection/Rupture of aneurysmal aortas
♀️➡️40% more likely aortic death
Estrogen
#VascularAging
#ArterialStiffness
Pregnancy & TAD
#AortaEd
#CircRes 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
Join us at #AGEAnnualMeeting2025 for Session 10: Aging on a Chip on May 14, 2025, from 1:00 PM to 2:30 PM at Tikahtnu Ballroom.
Speakers: Erika Moore, Dominick Rodriguez, Young Jang, Sophia Mahoney, James McGrath
bit.ly/4cJx8Gd
#AgingOnAChip #VascularAging #Senolytics #MicrophysiologicalModels
#CalorieRestriction #VascularAging #Progeroid🐭
CR (30%⏬, 7- to 22-wk) in ERCC1Δ/−🐭 rescues #AorticAging
⏬elastin breaks
⏬proteoglycan
⏬MMPSense680
⏬ssDNA-cGAS-STING1
⏬inflamm VCAM1+ or LGALS3+ #SmoothMuscleCell
+Aortic bulk RNAseq
#Aging_Cell 2025
onlinelibrary.wiley.com/doi/10.1111/...
How are #EndothelialDysfunction & #ArterialStiffness are coupled in #vascularAging ?👇
Biomechanical #Aging of Aortas of eNOS -/+ -/- 🐭
1.5~12-mo
Beyond Press+Flow
Wall geometry + matrix architecture
Biaxial Active + passive mechanics
#AJPHeartCirc 2025
journals.physiology.org/doi/abs/10.1...
Functions & application of circRNAs in #VascularAging & aging-related vascular diseases
miR sponge
Linear mRNA translation
Interact with epigenetic/transcriptional machinery
Form R-loop on host gene
Protein-coding
#JNanobiotech 2025
jnanobiotechnology.biomedcentral.com/articles/10....
Single-cell omics🐭#OvarianAging
scRNAseq scATACseq
12- vs 3-mo
#Aging
1⃣Mesenchymal Phox2B/ESRRγ/HoxB7-TGFβ2➡️ #Fibrosis (steroidogenic stroma, fibroblast, theca, but NOT pericyte)
2⃣Granulosa cell HSPA5 #ATF3 ATF4➡️#ERStress
Any #VascularAging?
#GeroScience 2025
link.springer.com/article/10.1...
#SpaceVascularBiology #VascularAging
#VesselOnAChip
#EndothelialCell +PET membrane + #SmoothMuscleCell
#Microgravity (clinostat-simulated)
⬆️ #Senescence EC SMC
rescued by
1️⃣Laminar Shear
2️⃣EC-SMC co-culture
3️⃣ siRNA #Piezo1 in SMCs
Biosens Bioelectron 2024
www.sciencedirect.com/science/arti...
If interested in SMC EZH2 #ArterialStiffness #VascularAging, read another recent paper from Iris Jaffe Lab #CardiovascularResearch 2022
Smooth muscle mineralocorticoid receptor as an epigenetic regulator of vascular ageing
academic.oup.com/cardiovascre...
#EndothelialCell (Cdh5+) mTOR KO mice->
⏬Macrovascular & Microvascular #VascularAging (ROS, SASP, NO-Vasodilation)
⏫Glucose/Insulin/Pyruvate/Intralipid tolerance
Lifespan? Muscle? Hematopoiesis? Organ-specific Angiocrine?😁
#AgingCell 2023
onlinelibrary.wiley.com/doi/full/10....
