80-mer DNA aptamer as a selective marker for #Senescence
Targeting EDA-Fibronectin Kd 500~1000 pM
Label senescent cells in naturally aged🐭🫁
Aptamer binding ⬇️in 21-mo INK-ATTAC🐭 with p16 cells eliminated
#Aging_Cell 2025
onlinelibrary.wiley.com/doi/10.1111/...
Circulate Health Reveals Study Results on Therapeutic Plasma Exchange and Biological Age Reduction #United_States #Novato,_California #Circulate_Health #Therapeutic_Plasma #Aging_Cell
#CalorieRestriction #VascularAging #Progeroid🐭
CR (30%⏬, 7- to 22-wk) in ERCC1Δ/−🐭 rescues #AorticAging
⏬elastin breaks
⏬proteoglycan
⏬MMPSense680
⏬ssDNA-cGAS-STING1
⏬inflamm VCAM1+ or LGALS3+ #SmoothMuscleCell
+Aortic bulk RNAseq
#Aging_Cell 2025
onlinelibrary.wiley.com/doi/10.1111/...
#HutchinsonGilfordProgeriaSyndrome
HGPS hiPSC #EndothelialCell Secretome screening->
#Angiopoietin2 autocrine (⏫#Angiogenesis #NitricOxide) & paracrine (⏬ #SmoothMuscleCell death #Senescence)
#BaseEditing Progerin⏫Angpt2 & HGPS EC behaviors
#Aging_Cell 2024
onlinelibrary.wiley.com/doi/10.1111/...
#Oocyte #Aging #Heterochromatin
Mouse 9- vs 2-mo
Human <35 vs >35 y/o
Aging▶️
⏬Heterochromatin
⏫DNA damage
⏫Retrotransposon transcription dsRNA Dicer
Overexpression of Sirt1 or EZH2 in aged oocytes to rescue
#Aging_Cell 2022
onlinelibrary.wiley.com/doi/10.1111/...
In vivo & In vitro Causal evidence of #EndothelialCell #Senescence as a driver of #Aging-related Compromise of #BloodBrainBarrier
Old INK-ATTC🐭(p16-hi cell elimination)
Senescent+ Healthy EC co-culture
#Aging_Cell 2024
onlinelibrary.wiley.com/doi/full/10....
