Elamipretide/Bendavia (mitochondria membr stabilizer) for #AorticAging

Elamipretide in aged 24~27 mo🐭
👉⏫Complex II activity & Max coupled respiration
👉⏬MMP9 & elastin breaks (by >1/3)
👉⏬bulk RNAseq SenMayo score
👉But 5% ⏫Ascending aorticφ (SMC markers?)

bioRxiv 2025
www.biorxiv.org/content/10.1...

#CalorieRestriction #VascularAging #Progeroid🐭

CR (30%⏬, 7- to 22-wk) in ERCC1Δ/−🐭 rescues #AorticAging
⏬elastin breaks
⏬proteoglycan
⏬MMPSense680
⏬ssDNA-cGAS-STING1
⏬inflamm VCAM1+ or LGALS3+ #SmoothMuscleCell

+Aortic bulk RNAseq

#Aging_Cell 2025
onlinelibrary.wiley.com/doi/10.1111/...

Female-Specific Considerations in Aortic Health & Disease
#AortaEd #AortaIsAnOrgan

#AorticAging
#ThoracicAorticDisease
#AbdominalAorticAneurysm

Hypertensive disorders of Pregnancy

Must-read👍

#CJCOpen 2024
www.sciencedirect.com/science/arti...