Epigenetics Update - SETDB1 enables development beyond cleavage stages by extinguishing the MERVL-driven two-cell totipotency transcriptional program in the mouse embryo bit.ly/46anfiQ

#Epigenetics #SETDB1 #Totipotency
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Discover the breakthrough at epigenometech.com

#SETDB1 #EndogenousRetroVirus

Pax7+ #MuSC, but not Pdgfra+ FAP, SETDB1 KO🐭➡️defected #SkeletalMuscle Regeneration
50%⏬muscle mass

Loss of SETDB1-H3K9me3 in MuSC depresses ERV expression ▶️
⏫cGAC-STING-IRF3▶️
⏬proliferation ⏫cell death ⏫pro-inflamm cytokines

#DevCell 2025
www.cell.com/developmenta...

#TransposableElement #SETDB1

SETDB1-driven H3K9me3 formation repress transcription of evolutionary young LINE-1 retrotransposons in👤#NeuralProgenitorCell

Unaltered proliferation, neural stemness in 10-d post-CRISPR KO of SETDB1
How about aging/inflam?

bioRxiv 2025
www.biorxiv.org/content/10.1...

Enzymatic Gatekeeper: Controlling Potentially Harmful Genes Researchers have identified the enzyme SETDB1 as a key regulator in silencing transposable elements, preventing potential genomic instability and offering insights into therapeutic strategies for related diseases.

Discover how the enzyme SETDB1 acts as a genomic guardian, silencing 'jumping genes' to maintain cellular integrity. #Genetics #Epigenetics #SETDB1