Epigenetics Update - SETDB1 enables development beyond cleavage stages by extinguishing the MERVL-driven two-cell totipotency transcriptional program in the mouse embryo bit.ly/46anfiQ

#Epigenetics #SETDB1 #Totipotency
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Discover the breakthrough at epigenometech.com

Z-DNA formation regulates the totipotent-like state and primes Zscan4-dependent chromatin compartmentalization - Nature Structural & Molecular Biology Shajahan et al. unveil a repressive genomic compartment in totipotent-like cells, shaped by Zscan4 and guided by transient Z-DNA formation. This ‘Z compartment’ may be crucial for preserving totipoten...

Epigenetics Update - Z-DNA formation regulates the totipotent-like state and primes Zscan4-dependent chromatin compartmentalization go.nature.com/3OxrAXf

Jack-Christophe Cossec in NSMB

#Epigenetics #Totipotency #Chromatin

Hi-res insights without cell sorting; epigenometech.com

Very excited to announce that our collaborative study with @efapostolou29.bsky.social on the transcriptional mechanisms distinguishing totipotent and pluripotent cells has been published (link.springer.com/article/10.1...). #totipotency #ZGA #stemcells #epigenetics #chromatin

Epigenetics Update - N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells bit.ly/4quXN05

#Epigenetics #StemCells #ESCs #Totipotency
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Discover the breakthrough at epigenometech.com

New research article! 📰

Kamiyama et al. showed that caregiver identity during the first instar is a critical socioenvironmental cue determining nymph versus worker fate. 🔬
🔗 doi.org/10.1007/s000...

#SocialInsects #TermiteCaste #CasteDetermination #Epigenetics #Parthenogenesis #Totipotency

Now online!
This review explores the origin and evolution of #retrotransposons, focusing on how long interspersed element-1 & #EndogenousRetroviruses regulate pre-implantation development and contribute to cellular #totipotency. #medsky
#OpenAccess:

This review elucidates the expression dynamics of key #TransposableElements, particularly LINE-1, throughout preimplantation development, highlighting their contribution to the regulation of developmental progression and #totipotency. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

Coordinated repression of totipotency-associated gene loci by histone methyltransferase EHMT2 through binding to LINE-1 regulatory elements Mouse embryonic stem cells (mESCs) and other naive pluripotent stem cells can reverse typical developmental trajectories and, at low frequency, de-differentiate into 2-cell-like cells (2CLCs) that res...

More insights on how H3K9me restricts totipotency state

Coordinated repression of totipotency-associated gene loci by histone methyltransferase EHMT2 through binding to LINE-1 regulatory elements | BioRxiv

#Preprint #Totipotency #Pluripotency #Heterochromatin #LINE1
www.biorxiv.org/content/10.1...