#SmoothMuscleCell Mettl14, ⬆️in injured artery, aggravates #IntimalHyperplasia via ⏫nascent KLF4 & SERPINE1 mRNA synthesis (Not impacting mRNA stability)

Likely Mettl3, but not other m6A readers/writers/erasers, plays a minor role

@insight.jci.org 2025
insight.jci.org/articles/vie...

So Happy to contribute a small part to this work from my PhD supervisor, Dr. Xi-Long Zheng lab 😆

The role of epigenomic reader #BRD4 in #SmoothMuscleCell #Microtubule #Autophagy #Senescence #IntimalHyperplasia #VascularAging😎

#ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...

A biochemical XNOR gate (not (A ^ B)) in #IntimalHyperplasia & #SmoothMuscleCell Migration

Individual inhibitor everolimus (mTORi) or PAP-1 (Kv1.3i), but NOT a combination of these two, ⏬🐭👤 vascular neointima in vivo & SMC migration in vitro

#JAHA 2025
www.ahajournals.org/doi/10.1161/...