#HutchinsonGilfordProgeriaSyndrome

#Senescence/#Aging features of Isogenic HGPS #hiPSC-#EndothelialCell vs #SmoothMuscleCell

#Progerin <
Nuclear deformation <
#Senescence >
#DNADamage ~
#TelomereLength <
#Shelterin
#SASP
#Heterochromatin loss ~

#EHJOpen 2022
academic.oup.com/ehjopen/arti...

Genetic Architecture of Human #TelomereLength 🤠
N>460K #UKbiobank

TL: qPCR+Telseq (WGS, coverage-adjusted)➡️
PC1 TL surrogate; PC2 artefactual signal➡️
new GWAS common variants
ExWAS rare variants
Plasma Proteomics
#ClonalHematopoiesis driver genes

#NatureGenet 2024
www.nature.com/articles/s41...

Study links early-life tobacco exposure to accelerated aging, urging preventive action A recent study in Science Advances found that early-life tobacco exposure, including in-utero and early smoking initiation, accelerates biological aging, emphasizing the importance of reducing exposur...

Study links early-life tobacco exposure to accelerated aging, urging preventive action 🚭🧬⏳ www.news-medical.net/news/2024050... #Tobacco #BiologicalAging #HealthyAging #Aging #PublicHealth #PreventiveHealth #TelomereLength #Smoking