@erictopol wrote on X (4:04 p.m. · 3 jan. 2025
):
There is an increased risk of autoimmune diseases after Covid, and 2 constituents of the virome (anellovirus and HHV-6) may help to explain this link
https://www.nature.com/articles/s41588-024-02022-z
#NatureGenet a study of 5 different […]
GWAS #Glaucoma
Multitrait analysis of GWAS #PrimaryOpenAngleGlaucoma #IntraocularPressure #VeticalCuptoDiscRatio N>600k
Multiancestry meta-analysis
Validation 23andMe N>2.8M➡️
240 loci 😁
+TWAS pQTL PWAS tp prioritize causal variants & drug targets
#NatureGenet 2023
www.nature.com/articles/s41...
Human #Kidney #KidneyFibrosis
#SpatialTranscriptomics (Visium CosMx) + sc-/sn-RNAseq snATACseq ->
Fibrotic microenvironment gene signature predicts renal function decline
Kidney MultiOmics database
www.susztaklab.com/hk_genemap
susztaklab.com/samui
#NatureGenet 2024
www.nature.com/articles/s41...
Genetic Architecture of Human #TelomereLength 🤠
N>460K #UKbiobank
TL: qPCR+Telseq (WGS, coverage-adjusted)➡️
PC1 TL surrogate; PC2 artefactual signal➡️
new GWAS common variants
ExWAS rare variants
Plasma Proteomics
#ClonalHematopoiesis driver genes
#NatureGenet 2024
www.nature.com/articles/s41...
GWAMA Genome-wide association meta-analysis #AbdominalAorticAneurysm
14 cohorts
39k case + 1M ctrl
121 risk loci (97 new!)
Lipid & Non-Lipid genes; BOTH LDL-C & non-HDL-C
#PCSK9 KO🐭are resistant to elastase-induced #AAA
#AortaEd
#NatureGenet 2023
www.nature.com/articles/s41...
BANKSY
A #SpatialOMics R/Python analysis framework using Transcriptomic Neighborhood🤠
1⃣Distance-weighted mean gene expression of each cell's neighborhood
2⃣Azimuthal Gabor filter▶️Gradient of gene expression in each cell's neighborhood
#NatureGenet 2024
www.nature.com/articles/s41...
#CellCharter
A powerful single-cell #SpatialTranscriptomics analysis framework
Graph-based #DeepLearning
Spatial cluster:
Cell type
Different expression
Neighborhood enrichment
AND Shape!!!👹 - curl/elongation/linearity/purity
#NatureGenet 2024
www.nature.com/articles/s41...
