Increased Smoothened signaling promotes kidney fibrosis through inhibiting autophagy in fibroblasts

doi.org/10.1016/j.kint.2026.01.028

#OpenAccess #MedSky #NephSky #renalfibrosis #kidneyfibrosis

New meroterpenoids featuring a rare 3/5/6/6/11/6/6 fused-ring skeleton from Penicillium brefeldianum SMU03 and their antifibrotic activities Penicine A (1), a meroterpenoid featuring a novel 3/5/6/6/11/6/6 polycyclic backbone, together with two new metabolites, penicines B (2) and C (4), an…

Renal fibrosis drives chronic kidney disease progression.

New research shows Penicine A — a structurally unique fungal meroterpenoid — suppresses fibrosis in vitro and reveals biosynthetic clues for antifibrotic drug discovery.

Read more on ScienceDirect.

#KidneyFibrosis #NaturalProducts #CJNM

Excited to share our commentary: kidney-international.org/article/S008... in @kidneyint.bsky.social on a groundbreaking study by Li et al. in @science.org. Their study uncovered how hypoxia-responsive tRNA-derived small RNAs drive renal protection via regulating #RNAAutophagy. #tDRs #KidneyFibrosis

This study demonstrates that #SNAI1 overexpression induces #Proteome alterations, #Nucleolar stress, #RibosomeBiogenesis, #Senescence, & activation of the #DNAdamage response, pointing to it as a potent therapeutic target in #KidneyFibrosis. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...

Critical role of transcription factor SOX4 in tubular epithelial cell dedifferentiation and fibroblast activation during kidney fibrosis

doi.org/10.1016/j.kint.2025.08.030

#OpenAccess #NephSky #MedSky #CKD #kidneyfibrosis
@yalepathology.bsky.social

Antibody Therapy Blocks Gut Molecule Linked to Kidney Fibrosis

Researchers found the gut‑derived peptide corisin is elevated in diabetic kidney disease patients and that an antibody against it markedly reduced kidney fibrosis in mouse models. Read more: getnews.me/antibody-therapy-blocks-... #corisin #kidneyfibrosis

This week's #ThrowbackThursday in JHC: "Renal Mast Cell-Specific Proteases in the Pathogenesis of Tubulointerstitial Fibrosis."

Click to read for FREE: bit.ly/3XCbrRo

#mastcells #kidneyfibrosis #pathology

UBC9-associated SUMOylation contributes to β-catenin activation and kidney fibrosis

doi.org/10.1016/j.kint.2025.07.005

#NephSky #MedSky #renalfibrosis #kidneyfibrosis

Big congrats to everyone involved - it was a blast! 🎊 If you're interested in #multiomics integration or #kidneyfibrosis, check it out! ⬇️

The final version of our multi-omics study on kidney fibrosis is out now (tinyurl.com/kidneyfibMSB). Together w/ Pepperkok + Savitski labs @embl.org, we present a time-resolved #multiomics + computational network modeling approach in combination w/ phenotypic assays to study #kidneyfibrosis

Decoding kidney fibrosis with time-resolved multi-omics
#KidneyFibrosis #MultiOmics

Tuechler et al 2025, study led by Rainer Pepperkok @embl.org and @juliosaezrod.bsky.social

🆕 #preprintpeerreview by @reviewcommons.org

>> doi.org/10.1101/2024...

Repression of peroxisome proliferation-activated receptor γ coactivator-1α by p53 after #kidneyinjury promotes mitochondrial damage and maladaptive #kidney repair

doi.org/10.1016/j.kint.2025.02.009

#MedSky #NephSky #renalfibrosis #kidneyfibrosis #cisplatin #aki #acutekidneyinjury

The critical role of endoplasmic reticulum stress and the stimulator of interferon genes (STING) pathway in kidney fibrosis

doi.org/10.1016/j.kint.2024.10.021

#chronickidneydisease #ckd #kidneyfibrosis #PERK

Human #Kidney #KidneyFibrosis

#SpatialTranscriptomics (Visium CosMx) + sc-/sn-RNAseq snATACseq ->
Fibrotic microenvironment gene signature predicts renal function decline

Kidney MultiOmics database
www.susztaklab.com/hk_genemap
susztaklab.com/samui
#NatureGenet 2024
www.nature.com/articles/s41...