#MastCells #MastCellActivationSyndrome #MastCellActivation #MCAS #MCAD #HaT #Mastocytosis #MastCellActivationDisorder #MastCellDisorder #Neuroimmune #NeuroimmuneAxis #Histamine #Gastrointestinal #GastrointestinalHealth #GutBrain #GutBrainAxis

Don't forget to register for our Clinician's Roundtable this Friday with neurogastroenterologist Dr. Zac Spiritos!

If you have #MastCells #MCAS #MACD #Mastocytosis #HaT #Histamine on the mind, you'll want to learn about the brain-gut connection and treating gastric impacts!

Register ⬇️ #MedSky

Mast Cells Contribute to Pressure Overload-Induced Myocardial Hypertrophy by Upregulating TRPV4 via Histamine: Role of Ca2+/ CnA/NFATc3 Signaling Pathway

This study shows that #Histamine-driven #TRPV4 upregulation in #Cardiac #MastCells enhances #CalciumInflux, activating #Ca²⁺/CnA/#NFATc3 signaling and contributing to #Myocardial #Hypertrophy and #CardiacRemodelling. #medsky

To read: doi.org/10.1007/s115...

Often seen, rarely recognized: mast cell activation disease – a guide to diagnosis and therapeutic options You have to enable JavaScript in your browser's settings in order to use the eReader.

Often seen, rarely recognized: mast cell activation disease – a guide to diagnosis and therapeutic options

By Lawrence B. Afrin et al.

tandfonline.com/doi/epdf/10....

Annals of Medicine Volume 48, 2016 - Issue 3
#MCAS #MastCells

Protective and pathogenic roles for mast cells during viral infections

Abhay PS Rathore and Ashley L St John

ncbi.nlm.nih.gov/pmc/articles...

Curr Opin Immunol. 2020 Oct; 66: 74–81.
#MastCells #ViralInfections

#MastCells #LongCovid #allergies #MCAS

🧫 Today's read from our #Highlights2025 collection outlines a newly identified mechanism by which melanoma can suppress mast function.

📕 Melanoma cells suppress mast cell function via a melanin-dependent mechanism

Discover the article, here ➡️ buff.ly/VtV9chN

#mastcells #melanoma #melanin

Tryptase May Miss Gastrointestinal Mast Cells in Systemic Mastocytosis Immunohistochemical assessment of CD25 and CD117 more reliably detects gastrointestinal mastocytosis in SM with bone marrow involvement.

Gastrointestinal (#GI) mastocytosis is predictive of #SystemicMastocytosis (SM) involving the bone marrow, but only about one-third of those patients show GI positivity for #MastCells. Study in American Journal of Clinical Pathology.

Read more: https://bit.ly/44pK6Gd

“Egzaman var diye krem sürüp duruyorsun ama sorun cildinde değil…

Egzama bir cilt sorunu değil.
Biyolojik olarak bağırsak bariyerinin çöküşüdür.

#egzama
#atopikdermatit
#gutskinning
#bağırsakbariyeri
#leakygut
#inflamasyon
#mastcells
#eczacıtavsiyesi
#ciltbilimi
#immunoloji

IMAGE DESCRIPTION: Photo of a person with a red neck that they are scratching. Photo of someone holding a booklet. Heading - Download Mast Cell Action’s new booklet on MCAS. Mast Cell Action and ME Association logos

Mast Cell Action have produced a new summary booklet on Mast Cell Activation Syndrome, covering mast cells, MCAS symptoms, triggers, management, treatment and the histamine bucket theory.

Download the booklet to read more: https://tinyurl.com/238jv3th

#MCAS #MastCells #MECFS #LongCovid

Mosquitoes, Meridians, Mast Cells, and More | Acupuncture Today

acupuncturetoday.com/article/3986... #mosquitoes #acupuncture #qi #mastcells

The sensitising effect of IgG in fibromyalgia syndrome is mediated by Mrgprb2 in mast cells Fibromyalgia syndrome (FMS) is characterized by elevated levels of immunoglobulin G (IgG), altered bowel habits, and increased pain sensitivity, suggesting immune dysregulation, but the exact mechanis...

The sensitising effect of IgG in fibromyalgia syndrome is mediated by Mrgprb2 in mast cells

Karla R. Sanchez, Jamie Burgess, Qin Zheng, Uazman Alam, Harvey Neiland, Richard Berwick, David Andersson, Samantha Korver, Anne Marshall, Andreas Goebel, Xinzhong Dong

#Fibromyalgia #MastCells

What are high-histamine foods? Think histamine is just about allergy? Think again. We take a look at what histamine is and how the food we eat may affect our histamine levels

“some #histamine -producing #bacteria are..anaerobic, so vacuum-packing doesn’t inhibit them and higher levels of histamine are typically seen in leftover and out-of-date food.": buff.ly/pWItzIM

from BBCGoodFood
#leftovers #HealthyEating #Chronicillness #MastCells

Brayden Yellman, MD | Underappreciated Co-Morbidities in ME/CFS
video uploaded Oct. 16, 2025
youtu.be/od0epKW19og
#MECFS #MCAS #POTS #DrugRepurposing #hydroxyurea #MastCells #immunology

The Clinical Relevance of Mast Cell Activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

#MastCells #MCAS #ME #MECFS

The hEDS Immune Connection: What New Research Means for Your Health A breakthrough study shows that immune signaling, not just genetics, plays a major role in hEDS. Here’s how mast cells, inflammation, and your environment interact—and why it matters more than ever.

"Here’s the metaphor we’re going to use to explain it (pardon the crudeness):
#MastCells act like meat tenderizer on #ConnectiveTissue. They don’t destroy your tissue all at once. They quietly soften, weaken, and loosen it.": buff.ly/lwN4Q0I

via EDSShare
#EhlersDanlosSyndrome #hEDS #ChronicIllness

When You're Allergic to Everything and Nothing... That's MCAS An intro guide to Mast Cell Activation Syndrome and how it has fundamentally changed my life. Living under the constant threat of anaphylaxis is hard - but there are ways to make it easier.

“Staying ahead of my #MastCells is a #FullTimeJob ..It means I have almost no life as I MUST control my #environment at all times. Even with these changes - I still experience flares quite regularly.": buff.ly/x8WEt6z

by @Broadwaybabyto.bsky.social
#MCAS #ChronicIllness

Intuitive Eating vs. Mindful Eating–Which Is Better For You? (Some Tips For Folks With EDS, MCAS, &/or POTS) Have you ever thought about the difference between mindful eating and intuitive eating?  They are not the same thing, but both can be helpful approaches to nutrition when a person lives with E…

“Especially for those of us with #MCAS, #eating does become challenging..When our #MastCells go berserk no matter what we ingest, it is incredibly hard to not fall into #hypervigilance, extreme #dieting & magical thinking.": buff.ly/GVBCKnj

by @2heartswellness.bsky.social

This week's #ThrowbackThursday in JHC: "Renal Mast Cell-Specific Proteases in the Pathogenesis of Tubulointerstitial Fibrosis."

Click to read for FREE: bit.ly/3XCbrRo

#mastcells #kidneyfibrosis #pathology

When You're Allergic to Everything and Nothing... That's MCAS An intro guide to Mast Cell Activation Syndrome and how it has fundamentally changed my life. Living under the constant threat of anaphylaxis is hard - but there are ways to make it easier.

“Even #medications to TREAT the condition will often be a trigger..that’s how sensitive #MastCells can be. Even when you’re trying to calm them you could be triggering them with an additional ingredient or dye in the #medication": buff.ly/9AV5rZO

by @Broadwaybabyto.bsky.social
#MCAS #allergic

Allergic to Everything — The Mysteries of Mast Cells How one of the oldest components of the human immune system can trigger a mysterious and little-understood syndrome.

"It wasn’t until the 1950s that we learned that #MastCells release #histamine, a powerful #chemical responsible for the sneezing and runny nose of an #allergy, as well as #anaphylaxis, a life-threatening reaction.": buff.ly/UAQz5UE

via @discovermag.bsky.social

Does Mast Cell Activation Underlie Multiple Ills? Unclear... Miriam E. Tucker via Medscape, October 2024

buff.ly/48UxdFi

#EDS #MCAS #hEDS #HSD #POTS #Dysatuonomia #MastCells #Medicine #Science #Illness #ChronicIllness #NEISvoid #MedSky #Doctors #Zebras

During an allergic response, some immune cells digest others Mast cells lure and trap other immune cells during allergic reactions, using their compounds to increase inflammation in a process dubbed nexocytosis

In which mast cells are found to not only emit lots of mediators, but occasionally ingest other white blood cells like neutrophils and either consume them, or emit their contents too...😮
www.sciencenews.org/article/some...
#MCAS #Masto #MastCells #Immunology #EDS #HSD #NEISvoid #MedSky

Mast Cells Contribute to Pressure Overload-Induced Myocardial Hypertrophy by Upregulating TRPV4 via Histamine: Role of Ca2+/ CnA/NFATc3 Signaling Pathway

This study identifies that the upregulation of #TRPV4, driven by #Histamine from #Cardiac #MastCells, is crucial in pressure overload-induced #myocardial #hypertrophy through the Ca2+-induced activation of the CnA/NFATc3 signaling pathway. #medsky

Read: link.springer.com/article/10.1...

For instance, sometimes my skin conditions feel horrible. Rationally, I know they are not contagious, not my fault, & I have bad genes. My skin heals bad. I get scars that I still feel the wound like it is fresh. I have swelling everywhere, & my #MastCells are what give horrible rashes, hives, etc.

Turning the Pain up in Fibromyalgia (and ME/CFS?): The Antibody-Mast Cell Connection - Health Rising A study suggests that mast cell activation may be a key driver of chronic pain in fibromyalgia. Treatments are suggested.

Turning the Pain up in Fibromyalgia (and ME/CFS?): The Antibody-Mast Cell Connection

www.healthrising.org/blog/2025/07...

#fibromyalgia #mastcells #chronicfatigue #mcas #pain #health

The Next Thing You Smell Could Ruin Your Life Millions of people suffer debilitating reactions in the presence of certain scents and chemicals. One scientist has been struggling for decades to understand why—as she battles the condition herself.

But, like everything related to chemical intolerance, it's gotten complicated.

Read my piece to get the rest of the story: www.wired.com/story/multip...

#chemicalintolerance #multiplechemicalsensitivity #environmentalillness #mastcells #MCAS

The Next Thing You Smell Could Ruin Your Life Millions of people suffer debilitating reactions in the presence of certain scents and chemicals. One scientist has been struggling for decades to understand why—as she battles the condition herself.

If some perfumes give you a headache, you might have #TLT.

"...real and resistant to mainstream diagnosis or treatment."

#PostWorldWarII chemicals
#ChemicalSensitivity #OutGassing #MastCells #ImmuneSystem #MCAS #HouseholdToxins

www.wired.com/story/multip...

🎯 And I am so grateful for Professor Andrew Shaw's extremely enlightening answer (see the comment below the post) regarding the role of antispike IgE as a mechanism through which #mastcells are possibly activated in the Long Covid immune response.