Mast Cells Contribute to Pressure Overload-Induced Myocardial Hypertrophy by Upregulating TRPV4 via Histamine: Role of Ca2+/ CnA/NFATc3 Signaling Pathway

This study shows that #Histamine-driven #TRPV4 upregulation in #Cardiac #MastCells enhances #CalciumInflux, activating #Ca²⁺/CnA/#NFATc3 signaling and contributing to #Myocardial #Hypertrophy and #CardiacRemodelling. #medsky

To read: doi.org/10.1007/s115...