Mast Cells Contribute to Pressure Overload-Induced Myocardial Hypertrophy by Upregulating TRPV4 via Histamine: Role of Ca2+/ CnA/NFATc3 Signaling Pathway

This study shows that #Histamine-driven #TRPV4 upregulation in #Cardiac #MastCells enhances #CalciumInflux, activating #Ca²⁺/CnA/#NFATc3 signaling and contributing to #Myocardial #Hypertrophy and #CardiacRemodelling. #medsky

To read: doi.org/10.1007/s115...

New insights into the cardio-renal benefits of SGLT2 inhibitors and the coordinated role of miR-30 family

Reviewing SGLT2is in cardiovascular & renal diseases, its co-ordinated role with the miR-30 family in #EndothelialDysfunction & #CardiacRemodelling, & the role of circulating miR-30s as #biomarkers & targets in #Cardiovascular & #KidneyDiseases. #medsky

www.sciencedirect.com/science/arti...

Thank you A/Prof André @ALaGerche, Head of Clinical Research Domain, @BakerResearchAu for presenting this month's #BarbaraEllSeminar. Hosted by Institute’s Prof Diane @FatkinLab, A/Prof La Gerche discussed his research into #CardiacRemodelling in #athletes.
#CardioTwitter