Mast Cells Contribute to Pressure Overload-Induced Myocardial Hypertrophy by Upregulating TRPV4 via Histamine: Role of Ca2+/ CnA/NFATc3 Signaling Pathway

This study shows that #Histamine-driven #TRPV4 upregulation in #Cardiac #MastCells enhances #CalciumInflux, activating #Ca²⁺/CnA/#NFATc3 signaling and contributing to #Myocardial #Hypertrophy and #CardiacRemodelling. #medsky

To read: doi.org/10.1007/s115...

Mast Cells Contribute to Pressure Overload-Induced Myocardial Hypertrophy by Upregulating TRPV4 via Histamine: Role of Ca2+/ CnA/NFATc3 Signaling Pathway

This study identifies that the upregulation of #TRPV4, driven by #Histamine from #Cardiac #MastCells, is crucial in pressure overload-induced #myocardial #hypertrophy through the Ca2+-induced activation of the CnA/NFATc3 signaling pathway. #medsky

Read: link.springer.com/article/10.1...

高知県産のゆずエキスが皮膚バリア機能を強化する可能性 新たな研究により、ゆずの残さから抽出したエキスが細胞内のカルシウム濃度を上昇させ、皮膚のバリア機能を向上させる効果が示されました。最新の成果をお届けします。

高知県産のゆずエキスが皮膚バリア機能を強化する可能性 #高知県 #TRPV4 #POLA #ゆずエキス

新たな研究により、ゆずの残さから抽出したエキスが細胞内のカルシウム濃度を上昇させ、皮膚のバリア機能を向上させる効果が示されました。最新の成果をお届けします。

TRPV4 activation in Schwann cells mediates mechanically induced pain of oral cancer - PubMed TRPV4 activation plays a role in mediating mechanically induced pain of oral cancer.

TRPV4 on Schwann cells is a potential mediator of mechanically induced pain in oral cancer, check out this article! #TRPV4 #oralcancerpain #Schwanncells pubmed.ncbi.nlm.nih.gov/40144515/

🚨🆕NIH-funded🔬by Harissa et al show TRPV4 mutations may disrupt chondrocyte 🦴 mechanotransduction- cartilage loses important gene responses to mechanical load, altering growth & ossification👉 journals.physiology.org/doi/abs/10.1...
#Cartilage #Science #TRPV4 #Physiology

Polyunsaturated fatty acids suppress PIEZO ion channel mechanotransduction in articular chondrocytes Chondrocytes sense mechanical signals from their environment via ion channels such as TRPV4 and Piezo1. The mechanosensitivity of these channels is altered by the presence of polyunsaturated omega-3 ...

Congrats to Gabi Marushack and @alisavadipour.bsky.social & team for our latest @Guilak_Lab paper showing that polyunsaturated fatty acids alter cell membrane properties & inhibit chondrocyte #mechanotransduction by #Piezo1 and #TRPV4. faseb.onlinelibrary.wiley.com/doi/10.1096/...