#Research
Matricellular protein #SMOC2 safeguards tubular integrity in acute #kidney injury via integrin β3-dependent inhibition of #CCND1-#CDK4/6 axis doi.org/10.1186/s435...
Researchers from University of Montreal
#SMOC2 #AcuteTubularInjury #RenalFibrosis #CellCycleArrest
Increased Smoothened signaling promotes kidney fibrosis through inhibiting autophagy in fibroblasts
doi.org/10.1016/j.kint.2026.01.028
#OpenAccess #MedSky #NephSky #renalfibrosis #kidneyfibrosis
#Research
Matricellular protein #SMOC2 safeguards tubular integrity in acute #kidney #injury via integrin β3-dependent inhibition of #CCND1-#CDK4/6 axis doi.org/10.1186/s435...
#CellCycleArrest #DNAdamage #RenalFibrosis
TRPC6 Knockout Alleviates Renal Fibrosis through PI3K/AKT/GSK3B Pathway
TRPC6 knockout alleviates #RenalFibrosis by reducing fibrotic markers, #apoptosis, and #inflammation, while downregulating the PI3K/AKT/GSK3β pathway—supporting TRPC6 inhibition as a promising therapeutic strategy for #ChronicKidneyDisease.
Read more: doi.org/10.1007/s115...
This review highlights #StemCellDerived #exosomes as promising anti‑fibrotic and regenerative therapies for #RenalFibrosis, comparing them with stem cell treatments and discussing future strategies to enhance #kidney protection.
OpenAccess: doi.org/10.1016/j.ge...
This review highlights #StemCellDerived #exosomes as promising anti‑fibrotic and regenerative therapies for #RenalFibrosis, comparing them with stem cell treatments and discussing future strategies to enhance #kidney protection.
OpenAccess: doi.org/10.1016/j.ge...
UBC9-associated SUMOylation contributes to β-catenin activation and kidney fibrosis
doi.org/10.1016/j.kint.2025.07.005
#NephSky #MedSky #renalfibrosis #kidneyfibrosis
TRPC6 knockdown alleviates #RenalFibrosis by reducing the expression of #fibrotic markers and mitigating #apoptosis and #inflammation of primary tubular epithelial cells (PTECs) via downregulating the PI3K/AKT/GSK3β pathway. #medsky
#MostDownloaded: link.springer.com/article/10.1...
Online today! Loss of p300 in proximal tubular cells reduces #RenalFibrosis and endothelial-mesenchymal transition.
By Hyunsik Kim, Beom Seok Kim, Beom Jin Lim, Ho-Geun Yoon & colleagues at Yonsei University College of Medicine Seoul
🗞️ doi.org/10.1038/s443...
Repression of peroxisome proliferation-activated receptor γ coactivator-1α by p53 after #kidneyinjury promotes mitochondrial damage and maladaptive #kidney repair
doi.org/10.1016/j.kint.2025.02.009
#MedSky #NephSky #renalfibrosis #kidneyfibrosis #cisplatin #aki #acutekidneyinjury
