🔬 #Trypanosomes process their large rRNA in a highly unusual way-by cutting it into six pieces. A new study from @schneian.bsky.social lab identified two essential proteins, TbLrRP1 and TbLrRP2, that drive this process. Read more: doi.org/10.1093/nar/...
#NARBreakthrough #RibosomeBiogenesis

This study demonstrates that #SNAI1 overexpression induces #Proteome alterations, #Nucleolar stress, #RibosomeBiogenesis, #Senescence, & activation of the #DNAdamage response, pointing to it as a potent therapeutic target in #KidneyFibrosis. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...

🔬 Meet Dr. Brigitte Pertschy – Key Researcher @uni-graz.at & Head of our Training Unit
She studies how ribosomes are built & how this process changes as we age.

💡 Recently awarded a €10M @erc.europa.eu Synergy Grant for the project 'snoOPERA'! Congrats!

#MetAGE #HealthyAging #RibosomeBiogenesis

This review explores how #RibosomeBiogenesis, involving rRNA, ribosomal proteins, and biogenesis factors, impacts #LiverRegeneration, #HepatitisC, #NAFLD, and #LiverCancer, emphasizing its potential as a novel therapeutic strategy. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

The mitochondrial methylation potential gates mitoribosome assembly Nature Communications - Here, using long-read RNA sequencing, SILAC proteomics, and cryo-EM, the authors show that loss of mitochondrial methylation impairs rRNA processing and ribosome maturation,...

@wredenberglab.bsky.social @ruthicglasgow.bsky.social
No SAM? Mitoribosome assembly stalls. Cryo-EM reveals methylation is essential for peptidyl center formation.
Congrats to authors 🎉
Stay tuned to hear more about mitoSAM role in different tissues
#Mitochondria #RibosomeBiogenesis
rdcu.be/etStQ

This article reviews the mechanism of #ribosome progression in the #liver, offering new insights into the relationship between #RibosomeBiogenesis and the liver, while also exploring potential therapeutic approaches. #medsky

#OpenAccess:
www.sciencedirect.com/science/arti...

Ribosome biogenesis emerges as a central player in liver diseases, influencing cellular function and disease progression. This cutting-edge study highlights its pivotal role and potential as a therapeutic target. #LiverHealth #RibosomeBiogenesis www.sciencedirect.com/science/arti...

DEAD-box RNA helicase 10 is required for 18S rRNA maturation by controlling the release of U3 snoRNA from pre-rRNA in embryonic stem cells Nature Communications - Ribosome biogenesis is crucial for maintaining stem cell homeostasis. Here, authors reveal that DDX10 plays a critical role in ribosome biogenesis by regulating 18S rRNA...

New from the Yao's lab: DDX10 (Dbp4 in yeast) controls the release of U3 snoRNA during ribosome biogenesis. #RNABiology #Ribosome #RibosomeBiogenesis rdcu.be/d2y3R

Can I be added as well :) #RibosomeBiogenesis