PCK1 suppresses #HepatocellularCarcinoma stemness & #tumorigenesis by activating the #HippoPathway via YAP inhibition, enhances #sorafenib sensitivity, and supports combined therapy with verteporfin as a promising strategy against #LiverCancer.
#OpenAccess: doi.org/10.1016/j.ge...
#Exosomal lnc-TAF12–2:1 is upregulated in #BladderCancer, driving proliferation by sponging miR-7847–3p to stabilize ASB12; its inhibition suppresses #tumorigenesis, positioning it as a novel diagnostic and therapeutic #biomarker.
#OpenAccess: doi.org/10.1016/j.ge...
This review highlights the role of SUMO #E3Ligase #RANBP2 in cell cycle control and #tumorigenesis, identifying this nuclear pore complex protein as a promising yet underexplored target for #SolidTumors needing clinical validation.
#OpenAccess: doi.org/10.1016/j.ge...
In @jhumimmunity.org, Tomomasa, Nishimura, Kanegane et al. investigated #tumorigenesis mechanisms through transcriptomic profiling and somatic variant analysis in tumor samples from six patients with X-linked lymphoproliferative syndrome type 1 (XLP1). rupress.org/jhi/article/...
Tomomasa, Nishimura, Kanegane et al. investigated #tumorigenesis mechanisms through transcriptomic profiling and somatic variant analysis in tumor samples from six patients with X-linked lymphoproliferative syndrome type 1 (XLP1). rupress.org/jhi/article/...
#InbornErrorsOfImmunity
An overview of #OncolyticVirus (OV) therapy, detailing multimodal mechanisms targeting #Tumorigenesis and #Metastasis while addressing current clinical challenges and future perspectives for enhanced efficacy.
#STTT #OpenAccess: doi.org/10.1038/s413...
#YTHDF1 drives #ColorectalCancer stemness, #tumorigenesis, and #chemoresistance by enhancing m6A-dependent #NOTCH1 translation, while its inhibition suppresses #tumor growth and improves chemotherapy response.
#OpenAccess in #STTT: doi.org/10.1038/s413...
An overview of glutamine (Gln) metabolism, its dual role in #Tumorigenesis, and crosstalk between glutamine metabolism & tumor stromal components, while discussing potential anti-tumor strategies targeting Gln metabolism.
#OpenAccess: doi.org/10.1016/j.ge...
Reviewing the #Biogenesis, characteristics, and functions of #eccDNA, and its role in regulating #Tumorigenesis & cancer treatment, with insights into its potential for inspiring precision medicine and identifying #PrognosticBiomarkers.
#OpenAccess: doi.org/10.1016/j.ge...
This review highlights #Chk2 as a regulator of #DNAdamage responses, #autophagy, and #homeostasis, linking its dysregulation to digestive‑system #tumorigenesis and therapy resistance, and positioning it as a promising #anticancer target.
#OpenAccess: doi.org/10.1016/j.ge...
This review shows how #methylation modulates #microRNA biogenesis, stability, and function, influencing proliferation, #apoptosis, #tumorigenesis, and #HostPathogenInteractions as a flexible layer of gene regulation.
#OpenAccess: doi.org/10.1016/j.ge...
An overview of the structure, activation, & regulation of EZH2 in human #Cancers and its role in #Tumorigenesis, while describing EZH2-targeting strategies to overcome therapy resistance and enhance #AntitumorImmunity.
#OpenAccess: doi.org/10.1016/j.ge...
Diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in Lung Squamous Cell Carcinoma
Diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in Lung Squamous Cell Carcinoma
#GDF10 expression levels reflect #Tumorigenesis & prognosis in #LungSquamousCellCarcinoma & also function as indicators of #Immune infiltration & checkpoint expression, promising a potential diagnostic & #Therapeutic #Biomarker. #medsky
To read: link.springer.com/article/10.1...
An overview of the relationship between ncRNAs (miRNAs, lncRNAs, & circRNAs) and #OxidativeStress in regulating different aspects of #Tumorigenesis — #EMT, #Autophagy, #Angiogenesis, energy metabolism, & proliferation.
#OpenAccess: doi.org/10.1016/j.ge...
This #STTT review outlines the #Epidemiology of virus-related tumors, detailing the mechanisms of #Oncogenic viral infection & #Tumorigenesis, while discussing the therapeutic strategies and advances in research.
#OpenAccess: doi.org/10.1038/s413...
This review summarizes the role of FGF15/19–FGFR4 signaling in regulating liver physiology and in pathogenesis of inflammation & #Tumorigenesis, highlighting its potential as a #Biomarker & #TherapeuticTarget in #LiverDiseases.
#OpenAccess: doi.org/10.1016/j.ge...
📰New & Featured | A new #Cell study: Chronic metabolic #stress/#HFDdiminishing #hepatocyte differentiation
🧐Early #lipid responses in hepatocytes, partly driven by #SOX4 activation and #HMGCS2 repression, activate multicellular stress circuits that prime #tumorigenesis.
The m6A reader #YTHDF1 drives #ColorectalCancer stemness, #tumorigenesis, and #chemoresistance by binding #m6A‑modified #NOTCH1; targeting YTHDF1 improves #chemotherapy efficacy, offering a promising therapeutic strategy. #medsky
#OpenAccess in #STTT: doi.org/10.1038/s413...
This review highlights how #cancer #organoids, which model #TumorHeterogeneity and physiology, are advancing studies of #tumorigenesis, #metastasis, #DrugScreening, & immunology, while outlining future prospects for organoid-based cancer therapy.
#OpenAccess: doi.org/10.1016/j.ge...
This review outlines the biology and function of tissue macrophages, their roles in health and disease, the contribution of #TumorAssociatedMacrophages to #Tumorigenesis, and emerging macrophage-targeted therapies.
#STTT #OpenAccess: doi.org/10.1038/s413...
This review highlights the role of #LKB1 in #Tumorigenesis and its therapeutic relevance in #Oncology, offering new insights into targeted #CancerTherapy. @westernu.bsky.social #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
This review highlights the role of #SLC7A11 in #Tumorigenesis through modulating ferroptotic responses, emphasizing its potential as a #therapeutic target to suppress #TumorProgression. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
This study elucidates the role of lnc-TAF12-2:1 in #BladderCancer (BCa) #Tumorigenesis, via the #miR-7847-3p/ASB12 axis, positioning lnc-TAF12–2:1 as a potential #MolecularTarget for #therapeutic intervention in BCa. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
An overview of #CancerStemCells (CSCs), their origins, associated signaling pathways, & their role in #tumorigenesis, with insights into CSC-targeting therapeutic strategies, their limitations, & future directions. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
A recent review offers valuable insights into the links between mitochondrial structure, genes, #Metabolism, and cell death in #Tumorigenesis, and explores #Mitochondria-targeted approaches as emerging strategies for #CancerTherapy. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
This latest review explores the role of miR-23b in #Cancer, showing how it drives #Tumorigenesis via #Wnt/β-catenin signaling and #Apoptotic proteins such as #BCL2, positioning miR-23b as a potential target in cancer prognosis and therapy. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
RESEARCH PAPER: Opposing lineage specifiers induce a pro-tumor hybrid identity state in lung adenocarcinoma
By Fort et al.
➡️ https://tinyurl.com/gd352742
#cancer #gastrointestinal #lung #transcriptionfactor #tumorigenesis #RAS/MEK #signaling #lineage #plasticity #cancertherapy
This study demonstrates that ELMOD2, a GTPase-activating protein, plays a significant role in #Glioma #tumorigenesis and has potential as a prognostic #biomarker and #therapeutic target for glioma. #medsky
Read more:
Synapse: Your Connection to our MSK Authors
Meet: Juan Yan
Research Focus: Human Oncology and Pathogenesis Program; Senior Research Scientist
synapse.mskcc.org/synapse/work...
#KMT2C #KMT2D #KMT2A #Epigenetics #UrothelialCancer #BladderCancer #Tumorigenesis #ChromatinBiology #GeneRegulation
This study reveals the dual role of SRSF1 in #tumorigenesis, showing that its inhibition by the novel inhibitor TN2008 boosts immunotherapy, highlighting it as a promising #CancerTherapy. @fudan-university.bsky.social #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
