Circ_0012152 Accelerates Acute Myeloid Leukemia Progression through the miR-652-3p/SOX4 Axis

Circ_0012152 is identified as an independent adverse #PrognosticFactor in #AcuteMyeloidLeukemia, with its upregulation promoting #leukemic cell growth and survival by sponging miR-652-3p to derepress #SOX4 and drive AML progression.

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📰New & Featured | A new #Cell study: Chronic metabolic #stress/#HFDdiminishing #hepatocyte differentiation
🧐Early #lipid responses in hepatocytes, partly driven by #SOX4 activation and #HMGCS2 repression, activate multicellular stress circuits that prime #tumorigenesis.