📰New & Featured | A new #Cell study: Chronic metabolic #stress/#HFDdiminishing #hepatocyte differentiation
🧐Early #lipid responses in hepatocytes, partly driven by #SOX4 activation and #HMGCS2 repression, activate multicellular stress circuits that prime #tumorigenesis.
In January's #EditorsChoice, Wu, @richardbartfai.bsky.social & co de-liver insights into improving organoid-derived #hepatocyte culture by analysing transcription factor networks
⚡https://doi.org/10.1242/dmm.052296
📰 doi.org/10.1242/dmm....
Left: representative images of livers with staining of the hepatocyte marker HNF4α, cholangiocyte marker CK19, the Kupffer cell marker CD68 or the endothelial cell marker CD31. Right: Schematic showing the regulation of JAK/STAT3 pathway by executioner caspases.
Some executioner caspases also have non-apoptotic functions. This study shows that sublethal executioner #caspase activation enhances #hepatocyte proliferation via JAK/STAT3 signaling, revealing a role for executioner caspases in promoting liver #regeneration @plosbiology.org 🧪 plos.io/3JEsH57
Left: representative images of livers with staining of the hepatocyte marker HNF4α, cholangiocyte marker CK19, the Kupffer cell marker CD68 or the endothelial cell marker CD31. Right: Schematic showing the regulation of JAK/STAT3 pathway by executioner caspases.
Some executioner caspases also have non-apoptotic functions. This study shows that sublethal executioner #caspase activation enhances #hepatocyte proliferation via JAK/STAT3 signaling, revealing a role for executioner caspases in promoting liver #regeneration @plosbiology.org 🧪 plos.io/3JEsH57
Left: representative images of livers with staining of the hepatocyte marker HNF4α, cholangiocyte marker CK19, the Kupffer cell marker CD68 or the endothelial cell marker CD31. Right: Schematic showing the regulation of JAK/STAT3 pathway by executioner caspases.
Some executioner caspases also have non-apoptotic functions. This study shows that sublethal executioner #caspase activation enhances #hepatocyte proliferation via JAK/STAT3 signaling, revealing a role for executioner caspases in promoting liver #regeneration @plosbiology.org 🧪 plos.io/3JEsH57
This recent paper discusses how hepatocytes directly recognize pathogens and upregulate hepcidin, independent of macrophage cytokine secretion. This positions hepatocytes as potential direct drivers of iron restriction during infections. Read more here 👉https://bit.ly/3XNL6km
#hematology #hepatocyte
DECISION consortium member Sophie Lotersztajn from the French research institute @inserm.fr at a late-afternoon abstract session today at #EASLCongress in Amsterdam, the Netherlands, about #fibrosis, #hepatocyte and #liver #regeneration. 🩺
#EASL2025 @easlnews.bsky.social
Schematic overview of insulin-responsive transcription factors and downstream-regulated genes dependent on or independent of p110α during HFD-induced obesity. Genes in blue are differentially expressed in p110αhep−/− mice during obesity. Genes in black are similarly expressed in p110αhep+/+ and p110αhep−/− mice fed an HFD.
Analysis of the effect of #hepatocyte p110α deletion on metabolic homeostasis in mice reveals that PI3Kα signaling is critical for the regulation of #liver gene expression and its reprogramming in the context of #HepaticSteatosis @plosbiology.org 🧪 plos.io/4jGLBoD
Schematic overview of insulin-responsive transcription factors and downstream-regulated genes dependent on or independent of p110α during HFD-induced obesity. Genes in blue are differentially expressed in p110αhep−/− mice during obesity. Genes in black are similarly expressed in p110αhep+/+ and p110αhep−/− mice fed an HFD.
Analysis of the effect of #hepatocyte p110α deletion on metabolic homeostasis in mice reveals that PI3Kα signaling is critical for the regulation of #liver gene expression and its reprogramming in the context of #HepaticSteatosis @plosbiology.org 🧪 plos.io/4jGLBoD
Schematic overview of insulin-responsive transcription factors and downstream-regulated genes dependent on or independent of p110α during HFD-induced obesity. Genes in blue are differentially expressed in p110αhep−/− mice during obesity. Genes in black are similarly expressed in p110αhep+/+ and p110αhep−/− mice fed an HFD.
Analysis of the effect of #hepatocyte p110α deletion on metabolic homeostasis in mice reveals that PI3Kα signaling is critical for the regulation of #liver gene expression and its reprogramming in the context of #HepaticSteatosis @plosbiology.org 🧪 plos.io/4jGLBoD
Quantify #hepatocyte samples with the accuracy of an expert technician, all in under a minute.
Learn more: buff.ly/otWli5i
#BioSky #AcademicChatter
Our feature-packed #hepatocyte counting algorithm provides a full picture of your sample:
☑️ Live / dead hepatocytes
☑️ Debris objects
☑️ Lymphocytes & non-parenchymal cells
☑️ Free nuclei
☑️ Automatic size and fluorescence gating
Learn more: https://buff.ly/4hbEofc
#HumanCells as #Art #Hepatocyte "Struck by its symmetry and beauty, Stolz snapped pictures of the cell at different layers and then used software to reconstruct and color the image." directorsblog.nih.gov/2014/11/13/s...
#NCB2024
In January, @steinaerts.bsky.social & co uncovered enhancer-gene regulatory networks underlying #hepatocyte identity and their zonation state by combining single-cell and spatial #multiomics with massively parallel reporter assays and deep learning.
www.nature.com/articles/s41...
#Hepatocyte #Mitchondria #Atherosclerosis
Mito-dependent/-independent roles of DRP1 in hepatic PCSK9 expression
Mdivi-1, a DRP1 inhibitor->
⏬SREBP-1c->⏬PCSK9 transcription
Modulating hepatocyte secretome->⏬PCSK9 secretion, ⏫PCSK9 degradation
#CardiovascRes 2021
academic.oup.com/cardiovascre...
