#Hepatocyte #Mitchondria #Atherosclerosis

Mito-dependent/-independent roles of DRP1 in hepatic PCSK9 expression

Mdivi-1, a DRP1 inhibitor->
⏬SREBP-1c->⏬PCSK9 transcription
Modulating hepatocyte secretome->⏬PCSK9 secretion, ⏫PCSK9 degradation

#CardiovascRes 2021
academic.oup.com/cardiovascre...