Circ_0012152 Accelerates Acute Myeloid Leukemia Progression through the miR-652-3p/SOX4 Axis

Circ_0012152 is identified as an independent adverse #PrognosticFactor in #AcuteMyeloidLeukemia, with its upregulation promoting #leukemic cell growth and survival by sponging miR-652-3p to derepress #SOX4 and drive AML progression.

Read more: doi.org/10.1007/s115...

#mTORC1 inhibition activates the integrated stress response, upregulates pro-apoptotic BMF, and sensitizes resistant T-ALL to #Venetoclax; Everolimus–Venetoclax synergy reduces #leukemic burden in #PDXmodels. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...