circSMAD2, an NSUN2‑mediated m5C‑dependent #circRNA, is upregulated in #PancreaticCancer and drives progression via TRIM59/AKT‑mTOR activation and IGF2BP1‑TPT1 scaffolding, marking it as an #oncogenic target.

#OpenAccess: doi.org/10.1016/j.ge...

Researchers identified CUDC-907, a dual PI3K/#HDAC inhibitor, to suppress #MEF2D fusion-driven BCP-ALL, inducing #Apoptosis and disrupting #Oncogenic signaling, highlighting its promise for precision therapy.

#STTT #OpenAccess: doi.org/10.1038/s413...

This review highlights #MYC as a central #oncogenic driver in #cancer, regulating proliferation, and #ImmuneEvasion, while exploring strategies to target MYC via MYC–MAX disruption, transcriptional control and synthetic lethal pathways.

#OpenAccess: doi.org/10.1016/j.ge...

This review highlights #HER3 as a key #oncogenic driver shaped by #TumorMicroenvironment signals, stressing the need for predictive #biomarkers, novel ADCs, and combination strategies to boost HER3-targeted #cancer therapies. @cwru.bsky.social

#OpenAccess: doi.org/10.1016/j.ge...

Long Non-coding RNA PCED1B Antisense RNA 1 Promotes Cell Proliferation and Invasion in Hepatocellular Carcinoma by Regulating the MicroRNA-34a/CD44 Axis

This study demonstrates that PCED1B-AS1 expression is upregulated in #HepatocellularCarcinoma, exerting an #Oncogenic role by promoting HCC cell proliferation and invasion via the miR-34a/CD44 axis. #Medsky
Read more: doi.org/10.1007/s115...

#Review in #MedComm_Biomaterails_and_Applicaitons
Exploring the Key Role of #Nanotechnology on Intratumoral Microbiome Modulation for #Cancer #Immunotherapy doi.org/10.1002/mba2...

#IntratumoralMicrobiome #TumorMicroenvironment #TME #microbial #Oncogenic #mechanism

This #STTT review outlines the #Epidemiology of virus-related tumors, detailing the mechanisms of #Oncogenic viral infection & #Tumorigenesis, while discussing the therapeutic strategies and advances in research.

#OpenAccess: doi.org/10.1038/s413...

This review highlights #IGF2BP1 as a key #m6A reader that drives #cancer hallmarks by promoting the translation of #oncogenic RNAs, linking its overexpression to poor prognosis and therapy resistance, and discussing its potential as a #biomarker.

#OpenAccess: doi.org/10.1016/j.ge...

#lncRNA USP30‑AS1 is identified as an #oncogenic driver in #BreastCancer, driving #tumor growth by repressing p21 through HnRNPF‑mediated mRNA destabilization & EZH2–c‑Myc activation, underscoring USP30‑AS1 as a #TherapeuticTarget. @tsinghua_uni

#OpenAccess: doi.org/10.1016/j.ge...

#RNase1 activates wild‑type ALK in non‑mutated #NSCLC, driving tumor growth and revealing a novel #oncogenic mechanism, with RDAA‑positive #tumors highly sensitive to FDA‑approved #ALKinhibitors. @mdanderson.bsky.social

#OpenAccess in #STTT: doi.org/10.1038/s413...

This review surveys #oncogenic #GeneFusions—particularly #TyrosineKinase fusions—examines detection methods, highlights targeted therapies, and underscores the importance of identifying fusion‑positive cancers. @gumedcenter.bsky.social

#OpenAccess #STTT: doi.org/10.1038/s413...

AI-enabled #Multiomics defined the EGC transition zone & identified a novel tumor-initiating inflammatory pit mucous cell, revealing unique ligand–receptor axes that amplify #Oncogenic pathways in early #GastricCancer.

#STTT #OpenAccess: doi.org/10.1038/s413...

This review outlines advances in targeting #oncogenic #KRAS, detailing #RASpathway biology, emerging inhibitors, and combination strategies, while also highlighting resistance mechanisms and current #ClinicalTrial progress. #cancer #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

Latest research shows that OBI-related pre-S point mutations trigger the Akt/mTOR/Cyclin D1 pathway, uncovering their #Oncogenic impact in #Hepatocarcinogenesis and therapy for #HBV-associated #HCC. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Researchers at @universidadoviedo.bsky.social showed that CDK7 therapy displays robust #AntiTumor activity by disrupting cell cycle progression & #Oncogenic signaling, positioning it as a promising #TherapeuticTarget for #HNSCC. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

This review highlights AXL as a key #oncogenic driver and #antiviral target, detailing its roles in #tumor progression and #DrugResistance, and explores emerging AXL-targeted therapies for improving outcomes in #cancer. @bostonchildrens.bsky.social

#STTT: doi.org/10.1038/s413...

This review highlights TET1, a key enzyme in #DNADemethylation, showing dual roles in #Cancer with both #Oncogenic and #Tumor suppressive properties, emphasizing the need for deeper mechanistic insights. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

This review examines highly #AggressiveCancers at the molecular levels, highlighting #oncogenic protein overexpression, and #DrugResistance, & discusses targeted single and combination therapies across multiple tumor types. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

This study shows that LATS1-regulated YAP1 phosphorylation and subcellular localization drives B-ALL #tumorigenesis, highlighting the #oncogenic role of YAP1 and its potential as a novel diagnostic and #TherapeuticTarget. #medsky

#MostDownloaded: link.springer.com/article/10.1...

#oncogenic potential 📌

Niemand wird sagen können er hätte es nicht gewusst ...

👀

Linking COVID-19 and cancer: Underlying mechanism COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), lead to a global health crisis with a spectrum of clinical manifestat…

It’s Covid.
SARS-Cov-2 is a known oncogenic mechanism which damages the immune system cells which act as killers of cancer cells
#CovidisNotOver #Sars-Cov-2
#Oncogenic #ColorectalCancer

www.sciencedirect.com/science/arti....

Nuclear and cytoplasmic USP30-AS1 coordinately regulate breast cancer progression through HnRNPF/p21 and EZH2/c-Myc/p21 axes

Researchers provide mechanistic insights into the #oncogenic role of USP30-AS1 in #BreastCancer progression via the HnRNPF/p21 and EZH2/c-Myc/p21 axis, highlighting it as a potential therapeutic target in breast cancer treatment. #lncRNAs #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

HER3: Unmasking a twist in the tale of a previously unsuccessful therapeutic pursuit targeting a key cancer survival pathway

This review describes the #oncogenic functions of HER3, explores the past & ongoing #ClinicalTrials on HER3-targeted therapies for various #cancers, and discusses how the #TumorMicroenvironment & other factors affect the outcome of these therapies. #medsky @cwru.bsky.social

buff.ly/7gdCHEo

Functional screen identifies RBM42 as a mediator of oncogenic mRNA translation specificity - Nature Cell Biology Kovalski et al. perform a genome-wide CRISPRi screen for selective MYC mRNA translation regulators and identify RBM42 as a ribosome-associated protein that modulates translation of MYC and an oncogeni...

☕️Kovalski et al. perform a genome-wide CRISPRi screen for selective MYC translation regulators and identify RBM42 as a ribosome-associated protein that modulates MYC translation and an #oncogenic mRNA program required for #PancreaticCancer growth.
👉🏼https://rdcu.be/ecb4e
bit.ly/41FKwY3

Targeting the MYCN-MDM2 pathways in cancer. Review alert

In this review, researchers at @uh.edu discuss the #oncogenic properties of MYCN, its molecular regulation, and the crosstalk between MYCN & MDM2, highlighting the strategies targeting MYCN/MDM2 for the treatment of #neuroblastoma & other cancers. #medsky
#OpenAccess:

www.sciencedirect.co...

Submit your poster abstracts by February 20 (11:59pm MST) to collaborate with Shannon Mumenthaler and other leading experts at the forefront of cancer and metabolism. Join us this March for our Tumor Metabolism meeting.

#KSTumorMetab25 #cancermetabolism #oncogenic #metabolism #keystonesymposia

Long noncoding RNA TUG1 promotes chondrosarcoma progression and M2 polarization

Dissecting the #oncogenic role of long non-coding RNA taurine up-regulated gene 1 (TUG1) in accelerating the progression of #chondrosarcoma (CHS). #Epigenetics

Read this #OpenAccess article: www.sciencedirect.co...

Screenshot of post by Dr Pat Soon-Shiong "This is a real concern. I now have colleagues treating 9, 10 and 11 year old children with colon cancer" #weararespirator #covidisnotover

#weararespirator
#covidisnotover
#oncogenic ?
😰😰😰

Possible cancer-causing capacity of COVID-19: Is SARS-CoV-2 an oncogenic agent? Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown diverse life-threatening effects, most of which are considered short-term. In a…

Possible cancer-causing capacity of #COVID19: Is #SARSCoV2 an #oncogenic agent?

www.sciencedirect.com/science/arti...