Researchers identified CUDC-907, a dual PI3K/#HDAC inhibitor, to suppress #MEF2D fusion-driven BCP-ALL, inducing #Apoptosis and disrupting #Oncogenic signaling, highlighting its promise for precision therapy.

#STTT #OpenAccess: doi.org/10.1038/s413...

Calcineurin-binding protein 1 (#CABIN1) directly binds to the #MEF2D #FusionProtein, thereby affecting cell survival and modulating the expression of core regulatory factors of BCP-ALL in the MEF2D::HNRNPUL1 cell lines.

#OpenAccess: doi.org/10.1038/s413...