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Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
3 months ago
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This review surveys #oncogenic #GeneFusions—particularly #TyrosineKinase fusions—examines detection methods, highlights targeted therapies, and underscores the importance of identifying fusion‑positive cancers. @gumedcenter.bsky.social

#OpenAccess #STTT: doi.org/10.1038/s413...

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Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
4 months ago
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High-frequency gain-of-function PTK2/FAK splicing alternatives in SCLC are associated with elevated #TyrosineKinase activity, sensitivity to FAK inhibitors, and poor #Prognosis, highlighting their therapeutic potential.

#OpenAccess: doi.org/10.1038/s413...

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Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
6 months ago
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RDAA, an #oncogenicdriver in non-mutated #NSCLC, demonstrates strong sensitivity to #FDA-approved #ALKinhibitors, highlighting a promising therapy option for patients lacking #TyrosineKinase mutations. @mdanderson.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

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Genetics in Medicine
Genetics in Medicine
@gimjournal.bsky.social
1 year ago
Screenshot of Graphical Abstract with heading that reads "INFANTILE MYOFIBROMATOSIS"

Screenshot of Graphical Abstract with heading that reads "INFANTILE MYOFIBROMATOSIS"

Novel germline intronic PDGFRB variant associated with infantile myofibromatosis is resistant to #targetedtherapy with imatinib bit.ly/3CpK32q #personalizedmedicine #tyrosinekinase

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Forneris Lab @UniPV
Forneris Lab @UniPV
@fornerislab.bsky.social
5 years ago

New @biorxivpreprint about our collaboration with the Gherardi group @unipv for #structuralbiology studies on MET receptor #tyrosinekinase and HGF mimic agonists #structuralbiology @DBB_UniPV x.com/biorxivpreprint/status/1...

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