Long noncoding RNA TUG1 promotes chondrosarcoma progression while driving M2 macrophage polarization.
#TUG1 #lncRNA #Chondrosarcoma #M2Polarization #TumorMicroenvironment #BoneCancer
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TUG1 drives #chondrosarcoma progression by stabilizing EZH2 via ALYREF and promoting H3K27me3-mediated CPEB1 repression, while exosomal TUG1 enhances M2 #MacrophagePolarization, fueling #tumor growth and #metastasis.

#OpenAccess: doi.org/10.1016/j.ge...

#BoneSarcoma #Sarcoma #Chondrosarcoma #Chemotherapy #Controversial

doi.org/10.1016/j.cr...

Chondrosarcoma Treatment Market Projects Strong Growth As Innovative Therapies Emerge Through 2036 The chondrosarcoma treatment market is set for notable growth as new therapies and improved healthcare strategies emerge. Insights reveal promising advancements for patients.

Chondrosarcoma Treatment Market Projects Strong Growth As Innovative Therapies Emerge Through 2036 #United_States #Las_Vegas #Tibsovo #ozekibart #Chondrosarcoma

Man at lectern smiling

ChonDRAgon study design. Patients allowed to crossover to ozekibart at progression

KM curve with PFS at 12 mo of 21.7%

Tornado plot of TRAE with fatigue, diarrhea, nausea, and elevated LFTs highest

.@RobinL_Jones @royalmarsden presenting ChonDRAgon PhII registrational study of Ozekibart in conventional #chondrosarcoma #CTOS2025.

- No approved systemic therapies
- mPFS 5.5 mo, with 21.7% w/o prog @ 12 mo
- Activity in both IDH-WT & mut
- TRAE incl ~13% fatigue, ~6% hepatitis

Inhibrx Reports Impressive Third Quarter 2025 Financial Outcomes and Clinical Progress Inhibrx Biosciences disclosed its positive third-quarter finances for 2025, highlighting significant clinical advancements and ongoing trials.

Inhibrx Reports Impressive Third Quarter 2025 Financial Outcomes and Clinical Progress #USA #San_Diego #Inhibrx_Biosciences #INBRX-109 #Chondrosarcoma

This study uncovers the oncogenic role of TUG1 in #Chondrosarcoma and its interactions with the downstream regulatory axis, providing novel insights into the tumorigenic mechanisms of CHS. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Conventional Chondrosarcoma! Rare, Chemoresistant, Primary Bone Cancer: Radiology, Pathology, Treatment and Prognosis Chondrosarcoma, although rare, is the second most common bone sarcoma or primary bone cancer. There are several types of chondrosarcomas and each with their own characteristics.

Check out my new article on #Chondrosarcoma
#orthopediconcology #sarcoma #savelimbs

www.linkedin.com/pulse/conven...

📊 How Good Is #Radiomics Research in Bone #Chondrosarcoma?

This review assessed 18 radiomics studies using METRICS and RQS scoring systems.

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Bone Cancer Treatment Success Rate: What Patients Should Know - OncoDaily Learn about the bone cancer treatment success rate, including survival by type, remission possibilities, and factors that impact curability and long-term outcomes.

Bone Cancer Treatment Success Rate: What Patients Should Know

oncodaily.com/oncolibrary/...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #BoneCancer #BoneTumor #Chondrosarcoma #EwingSarcoma #MetastaticBoneCancer #Osteosarcoma #Sarcoma

Orthopedic Oncology Experts Shape Global Consensus on Chondrosarcoma Management R. Lor Randall, MD, FACS, discusses the importance of orthopedic oncology consensus meetings and the need for agreement about certain surgical practices.

Orthopedic Oncology Experts Shape Global Consensus on Chondrosarcoma Management @rlrandallmd.bsky.social @ucdavishealth.bsky.social #chondrosarcoma www.onclive.com/view/orthope...

Exciting advancements in #chondrosarcoma research! A recent study has identified new potential therapeutic targets, including immune checkpoint dysregulation, offering hope for new treatment strategies along with ongoing efforts to target IDH signaling. buff.ly/SyhdDvU #sarcoma #CureSarcoma #cancer

a woman with gray hair is sitting in front of a sign that says por 10 on it ALT: a woman with gray hair is sitting in front of a sign that says por 10 on it

At the same 11:30 my nurse told me “ok don’t worry I’ll let you sleep. I’m not going to bother you again tonight. See you in the morning”

I, Ever a skeptic, asked “when is the next medication due?”

“3a”

“And I think the care partner said vitals are at 2?”

#teamtangerine #chondrosarcoma #cancer

Lecture: Infection Mimics

10 mins lecture on differentiating osteomyelitis from other mimics such as tumors, LCH, CNO and stress and insufficiency fractures

www.bstneoplasms.com/p/lecture04/

#bstneoplasms #radres #focalbonelesion #osteomyelitis #tumor #chondrosarcoma #CNO #LCH #stress#

Long noncoding RNA TUG1 promotes chondrosarcoma progression and M2 polarization

Dissecting the #oncogenic role of long non-coding RNA taurine up-regulated gene 1 (TUG1) in accelerating the progression of #chondrosarcoma (CHS). #Epigenetics

Read this #OpenAccess article: www.sciencedirect.co...

Long noncoding RNA TUG1 is driving chondrosarcoma progression and promoting M2 macrophage polarization. This study sheds light on its role in tumor growth and immune modulation, opening doors for new therapeutic strategies. #Chondrosarcoma #lncRNA #Immunotherapy www.sciencedirect.com/science/arti...

Long noncoding RNA TUG1 is driving chondrosarcoma progression and promoting M2 macrophage polarization. This study sheds light on its role in tumor growth and immune modulation, opening doors for new therapeutic strategies. #Chondrosarcoma #lncRNA #Immunotherapy www.sciencedirect.com/science/arti...

Long noncoding RNA TUG1 drives chondrosarcoma progression and M2 macrophage polarization, presenting a new therapeutic target. #CancerResearch #Chondrosarcoma #RNA Read more: www.sciencedirect.com/science/arti...