The Histone Methyltransferase KMT2D is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration Resistant Prostate Cancer Abstract. Castration-resistant prostate cancer (CRPC) is largely dependent on the androgen receptor (AR) for growth and often exhibits hyperactive PI3K signaling, most frequently due to PTEN loss. The...

Epigenetics Update - The Histone Methyltransferase KMT2D is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration Resistant Prostate Cancer bit.ly/4a8C1cI

#Epigenetics #KMT2D #Cancer #CRPC

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Synapse: Your Connection to our MSK Authors
Meet: Juan Yan
Research Focus: Human Oncology and Pathogenesis Program; Senior Research Scientist

synapse.mskcc.org/synapse/work...

#KMT2C #KMT2D #KMT2A #Epigenetics #UrothelialCancer #BladderCancer #Tumorigenesis #ChromatinBiology #GeneRegulation