PCK1 suppresses #HepatocellularCarcinoma stemness & #tumorigenesis by activating the #HippoPathway via YAP inhibition, enhances #sorafenib sensitivity, and supports combined therapy with verteporfin as a promising strategy against #LiverCancer.

#OpenAccess: doi.org/10.1016/j.ge...

¿Se puede frenar la grasa con un interruptor genético? Interruptor epigenético con YAP y TAZ bloquea células grasas en ratones y reprograma PPARγ, abriendo pistas para obesidad y diabetes tipo 2. Un equipo del Instituto Coreano Avanzado de Ciencia y Tecno...

¿Se puede frenar la grasa con un interruptor genético? #Ciencia #Salud #Obesidad #DiabetesTipo2 #Genetica #Epigenetica #Biomedicina #Investigacion #HippoPathway #YAP #TAZ #KAIST #ScienceAdvances #1defebrero #felizdomingo donporque.com/frenar-la-gr...

Paper is out!

We establish evaluate compounds targeting the #Hippopathway.
We utilise an isogenic #mesothelioma model, functional assays, high-content & #Cellpainting to asses #YAP/TAZ-TEAD inhibitors.
@edinuni-irr.bsky.social @lsajournal.org

www.life-science-alliance.org/content/8/10...

Development of a pipeline to evaluate YAP-TEAD inhibitor potential - direct TEAD inhibition represses cancerous growth in a NF2-mutant model of mesothelioma As the core, tumorigenic downstream effectors of the Hippo signalling pathway, YAP/TAZ and the TEAD family of transcription factors represent attractive targets for drug discovery efforts within cance...

Our preprint from last week.

Development of a pipeline to evaluate YAP-TEAD inhibitor potential
www.biorxiv.org/content/10.1...

#mesothelioma, #cell-painting and #Hippopathway

Back from the excellent #Hippopathway conference in Florida. What a lovely bunch of people, and exciting developments in the field. #Cancer, #Regeneration and #Fibrosis etc.
Great Science, and even saw a "rocket". Hard to beat for the next conference....