YTHDF1 regulates chemotherapy response by suppressing NOTCH1-induced stemness in colorectal cancer.
RNA regulation intersects with treatment resistance.
doi.org/10.1038/s413...
#ColorectalCancer #YTHDF1 #NOTCH1 #CancerStemness #ChemotherapyResponse #Epitranscriptomics
#YTHDF1 drives #ColorectalCancer stemness, #tumorigenesis, and #chemoresistance by enhancing m6A-dependent #NOTCH1 translation, while its inhibition suppresses #tumor growth and improves chemotherapy response.
#OpenAccess in #STTT: doi.org/10.1038/s413...
The m6A reader #YTHDF1 drives #ColorectalCancer stemness, #tumorigenesis, and #chemoresistance by binding #m6A‑modified #NOTCH1; targeting YTHDF1 improves #chemotherapy efficacy, offering a promising therapeutic strategy. #medsky
#OpenAccess in #STTT: doi.org/10.1038/s413...
