This #STTT study shows that #Osimertinib disrupts the MYLK4–CDKAL1 interaction, inhibits pT43-CDKAL1 phosphorylation, and CDKAL1-dependent SALL2 translation to inhibit #CancerStemness & #Chemoresistance in #Rhabdomyosarcoma.

#OpenAccess: doi.org/10.1038/s413...

YTHDF1 regulates chemotherapy response by suppressing NOTCH1-induced stemness in colorectal cancer.
RNA regulation intersects with treatment resistance.
doi.org/10.1038/s413...
#ColorectalCancer #YTHDF1 #NOTCH1 #CancerStemness #ChemotherapyResponse #Epitranscriptomics

Scientists show that MTFR1 drives #BreastCancer growth via DRP1‑dependent mitochondrial fission & AKT/mTOR signaling, promotes #chemoresistance by altering #apoptosis and #CancerStemness, and identifies the MTFR1/DRP1 axis as a predictive #biomarker.

#OpenAccess: doi.org/10.1016/j.ge...

Dysadherin/YAP axis fuels stem plasticity and immune escape in liver cancer - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Dysadherin/YAP axis fuels stem plasticity and immune escape in liver cancer

Scientists identify #Dysadherin as an upstream activator of the FAK/YAP/TEAD2 axis in #HCC, showing it drives #CancerStemness and #ImmuneEvasion, while genetic or peptide inhibition restores #antitumor immunity and improves therapy response.

#OpenAccess #STTT: doi.org/10.1038/s413...

SNCA is epigenetically silenced early in #BreastCancer, where low expression predicts poor survival; restoring SNCA suppresses #TumorGrowth and #CancerStemness while promoting #Apoptosis through activation of a TP53AIP1–p53 feedback loop.

#OpenAccess: doi.org/10.1016/j.ge...

Psychological stress enhances #BreastCancer stemness by altering #GutMicrobiome composition, while supplementation with A. muciniphila or butyrate reverses stress-induced #Carcinogenesis and #CancerStemness. #medsky

#OpenAccess: doi.org/10.1038/s413...

Reviewing the role of #epigenetic alterations on #CancerStemness, with a discussion on the therapeutic strategies targeting epigenetic modifiers to eliminate #CancerStemCells. #medsky @foxchasesurgonc.bsky.social

Read this #STTT #OpenAccess: doi.org/10.1038/s413...

This study shows that #GutDysbiosis induced psychological stress promotes breast #CancerStemness via the LRP5/β-catenin pathway and highlights the role of A. muciniphila and butyrate as potential #biomarkers. #BreastCancer #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

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Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

➡️ buff.ly/ZscdSzr

#Sumoylation #CancerStemness #BCSM

This study shows that RAB26 promotes the proliferation, migration, and invasion of #ProstateCancer cells, inhibits #apoptosis, and enhances the #CancerStemness and sphere formation of prostate cancer stem cells (PCSCs) via the MAPK/ERK-TWIST1 signaling axis. #medsky

#OpenAccess: buff.ly/pUzCa8N

Arenobufagin suppresses the progression of early-stage hepatocellular carcinoma by inhibiting EpCAM-mediated tumor stemness EpCAM promotes cancer stemness and early-stage HCC progression, counteracted by arenobufagin, a potential therapeutic targeting EpCAM.

#EpCAM promotes #cancerstemness and #earlystageHCCprogression, counteracted by #arenobufagin, a potential therapeutic targeting EpCAM.

Read More: amm-journal.org/index.php/20...

#Epithelialcelladhesionmolecule @scienceopen.bsky.social

Analysis of SLC27A5-interacting proteins and in-depth #RNASequencing (RNA-seq) reveal that SLC27A5 promotes alternative polyadenylation of METTL14 which suppresses #CancerStemness in #HepatocellularCarcinoma.

#OpenAccess: https://buff.ly/4a9daUb