The dysadherin/CA9 axis shapes an acidic tumor microenvironment to promote colorectal cancer progression.
Microenvironmental acidity as a driver of malignancy.
doi.org/10.1038/s413...
#ColorectalCancer #TumorMicroenvironment #CA9 #Dysadherin #TumorAcidity #CancerProgression

The dysadherin/CA9 axis shapes an acidic tumor microenvironment to promote colorectal cancer progression.
Microenvironmental acidity as a driver of malignancy.
doi.org/10.1038/s413...
#ColorectalCancer #TumorMicroenvironment #CA9 #Dysadherin #TumorAcidity #CancerProgression

#Dysadherin drives #ColorectalCancer adaptation to acidic #TumorMicroenvironments by activating integrin–FAK–STAT3 signaling to upregulate CA9, promoting survival, metabolic reprogramming, and progression.

#OpenAccess in #STTT: doi.org/10.1038/s413...

#Dysadherin drives #ColorectalCancer adaptation to acidic #TumorMicroenvironments via integrin/FAK/STAT3‑mediated CA9 upregulation, sustaining pH #homeostasis and establishing the dysadherin–CA9 axis as a targetable driver of CRC progression.

#STTT: doi.org/10.1038/s413...

Dysadherin/YAP axis fuels stem plasticity and immune escape in liver cancer - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Dysadherin/YAP axis fuels stem plasticity and immune escape in liver cancer

Scientists identify #Dysadherin as an upstream activator of the FAK/YAP/TEAD2 axis in #HCC, showing it drives #CancerStemness and #ImmuneEvasion, while genetic or peptide inhibition restores #antitumor immunity and improves therapy response.

#OpenAccess #STTT: doi.org/10.1038/s413...